ArticleBritish heart journal1995
Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms.
Article in British heart journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03193294 (CORonary MICrovascular Angina), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Shedding Light on Treatment Options for Coronary Vasomotor Disorders: A Systematic Review.Cardiovascular drugs and therapy · 2024Pooled it
- Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial.Circulation · 2024Trial
- Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction.European heart journal · 2020Trial
- Coronary Artery Spasm: From Physiopathology to Diagnosis.Life (Basel, Switzerland) · 2025Review
- Coronary microvascular dysfunction, arrythmias, and sudden cardiac death: A literature review.American heart journal plus : cardiology research and practice · 2024Article
- Circulating Biomarkers in Coronary Microvascular Dysfunction.Journal of the American Heart Association · 2023Review
- Mechanistic study of the effect of Endothelin SNPs in microvascular angina - Protocol of the PRIZE Endothelin Sub-Study.International journal of cardiology. Heart & vasculature · 2022Article
- Dual pathway inhibition as compared to acetylsalicylic acid monotherapy in relation to endothelial function in peripheral artery disease, a phase IV clinical trial.Frontiers in cardiovascular medicine · 2022Article
- Elevated serum endothelin-1 is an independent predictor of coronary microvascular dysfunction in non-obstructive territories in patients with coronary artery disease.Heart and vessels · 2021Article
- Left ventricular mechanical dyssynchrony in patients with chest pain and normal epicardial coronary arteries.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure.ESC heart failure · 2020Article
- Treatment of coronary microvascular dysfunction.Cardiovascular research · 2020Review
- Endothelin-1 in hypertensive patients with ischemic heart disease.Internal and emergency medicine · 2019Article
- A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular anginga.Scientific reports · 2019Article
- Small-Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need, and Future Directions.Journal of the American Heart Association · 2019Review
- The Biochemical Markers Associated with the Occurrence of Coronary Spasm.BioMed research international · 2019Review
- Enhanced endothelin-1/Rho-kinase signalling and coronary microvascular dysfunction in hypertensive myocardial hypertrophy.Cardiovascular research · 2017Article
- A Brief History of Cardiac Syndrome X: A Biochemical View.The journal of Tehran Heart Center · 2017Article
- Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X.Anatolian journal of cardiology · 2016Observational
- Association of endothelial dysfunction and cytotoxin-associated gene A-positive Helicobacter pylori in patients with cardiac syndrome X.Biomedical journal · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome patients with angina pectoris and normal coronary arteriograms have reduced coronary flow reserve and abnormal endothelium dependent vasodilator responses. Endothelin-1 (ET-1), a potent vasoconstrictor, is an important modulator of microvascular function and may also have algogenic properties.
methodPlasma ET-1 was measured in peripheral venous blood in 40 patients (30 women) (mean (SD) age 56 (8) years) with angina and normal coronary arteriograms and 21 normal controls (17 women) (mean (SD) age 53 (7) years). Patients with systemic hypertension, left ventricular hypertrophy, or coronary spasm were excluded. Plasma ET-1 was measured using radioimmunoassay.
resultsThirty five patients had > or = 1 mm ST segment depression during exercise. Left bundle branch block was present in four patients at rest and in one during exercise. Mean (SD) (range) concentration of ET-1 (pg/ml) was higher in patients than in controls (3.84 (1.25) (1.97-7.42) v 2.88 (0.71) (1.57-4.48) P < 0.0001). In patients with "high" (> control mean (one SD)) ET-1 concentrations (n = 23), the time to onset of chest pain during exercise was significantly shorter (6.21 (3.9) v 9.03 (3.9) min; p = 0.01) than in patients with "low" ET-1 concentrations. Of the five patients with left bundle branch block, four had plasma ET-1 concentration > 4.0 pg/ml.
conclusionPlasma endothelin is raised in patients with angina and normal coronary arteriograms and is consistent with the demonstration of endothelial dysfunction in such patients. The association between "high" plasma ET-1 and an earlier onset of chest pain during exercise suggests that endothelin may also have a role in the genesis of chest pain in patients with normal coronary arteries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.