ArticleBehavior genetics1995
Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains.
Article in Behavior genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field.Genes, brain, and behavior · 2017Article
- Restraint stress increases hemichannel activity in hippocampal glial cells and neurons.Frontiers in cellular neuroscience · 2015Article
- Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder.Developmental neuroscience · 2012Article
- SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Sociability and motor functions in Shank1 mutant mice.Brain research · 2011Article
- Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.Behavioural brain research · 2010Article
- Cross-species assessments of motor and exploratory behavior related to bipolar disorder.Neuroscience and biobehavioral reviews · 2010Review
- Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.PloS one · 2009Article
- Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability.The European journal of neuroscience · 2009Article
- Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior.Molecular psychiatry · 2009Article
- Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.Behavioural brain research · 2007Article
- Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.Genetics · 2005Article
- Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis.Molecular psychiatry · 2003Article
- Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats.Neuropharmacology · 2002Article
- Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Increased anxiety of mice lacking the serotonin1A receptor.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Molecular pathways of anxiety revealed by knockout mice.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant inbred (RI) strains derived from the C57BL/6J and A/J mouse strains were used for behavioral studies designed to estimate the number and location of chromosomal loci responsible for anxiety-related behaviors and differential sensitivity to agonists and inverse agonists of the gamma-aminobutyric acidA (GABAA)/benzodiazepine receptor complex. The phenotypes of the parental inbred strains and of 28 RI strains were characterized for the number of transitions in the light<-->dark exploratory model, anxiolytic response to diazepam, vertical and ambulatory activities in an open field, and sensitivity to the convulsant properties of methyl-beta-carboline-3-carboxylate (beta-CCM). The strain distribution patterns and estimates of the minimal number of loci obtained for each trait suggest that multiple chromosomal loci contribute to differences in anxiety-related behavioral phenotypes and the behavioral responses to diazepam and beta-CCM between C57BL/6J and A/J mice. The best probabilities of linkage were found between the variables characterizing response to diazepam and loci on chromosomes 1 (Xmv-41) and 10 (D10Mit2) and between the sensitivity to the convulsant actions of beta-CCM and locus D15Mit5 on chromosome 15.
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Registered trials
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