ArticleAntimicrobial agents and chemotherapy1995
Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni.
Article in Antimicrobial agents and chemotherapy, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 98 citations in OpenAlex.
- Review
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2021Review
- Significant contribution of the CmeABC Efflux pump in high-level resistance to ciprofloxacin and tetracycline in Campylobacter jejuni and Campylobacter coli clinical isolates.Annals of clinical microbiology and antimicrobials · 2021Article
- Resistance to Antibiotics in Thermophilic Campylobacters.Frontiers in medicine · 2021Review
- Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.International journal of molecular sciences · 2020Article
- Enhanced resistance to fluoroquinolones in laboratory-grown mutants & clinical isolates of Shigella due to synergism between efflux pump expression & mutations in quinolone resistance determining region.The Indian journal of medical research · 2015Article
- Sequence variation in the outer membrane protein-encoding gene cmeC, conferring multidrug resistance among Campylobacter jejuni and Campylobacter coli strains isolated from different hosts.Journal of clinical microbiology · 2007Article
- Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli.Antimicrobial agents and chemotherapy · 2005Article
- Evidence for multiple-antibiotic resistance in Campylobacter jejuni not mediated by CmeB or CmeF.Antimicrobial agents and chemotherapy · 2005Article
- Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.Antimicrobial agents and chemotherapy · 2005Article
- Efflux-mediated drug resistance in bacteria.Drugs · 2004Review
- High-level beta-lactam resistance associated with acquired multidrug resistance in Helicobacter pylori.Antimicrobial agents and chemotherapy · 2003Article
- Antimicrobial-resistant Campylobacter species from retail raw meats.Applied and environmental microbiology · 2003Article
- CmeABC functions as a multidrug efflux system in Campylobacter jejuni.Antimicrobial agents and chemotherapy · 2002Article
- Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.Microbiology and molecular biology reviews : MMBR · 2001Article
- Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.Antimicrobial agents and chemotherapy · 2000Review
- Antibiotic resistance in Campylobacter strains isolated from animals, foods, and humans in Spain in 1997-1998.Antimicrobial agents and chemotherapy · 2000Article
- Diagnosis of quinolone-resistant Coxiella burnetii strains by PCR-RFLP.Journal of clinical laboratory analysis · 2000Article
- Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.Antimicrobial agents and chemotherapy · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms of drug resistance in Campylobacter jejuni were investigated. Mutant strains 34PEFr, which was resistant to pefloxacin (128-fold increase in the MIC), and 34CTXr, which was resistant to cefotaxime (32-fold increase in the MIC) and which was derived from the susceptible parent 34s, were obtained by serial passages on pefloxacin and cefotaxime gradient plates, respectively. Both mutants showed cross-resistance to erythromycin, chloramphenicol, tetracycline, beta-lactams, and quinolones. While the quinolone resistance of strain PEFr could be explained by a mutation at codon 86 of the gyrA gene, the multidrug resistance phenotype of both strains was further investigated. Accumulation of pefloxacin, ciprofloxacin, and minocycline was measured by fluorometry and was found to be lower in the mutant strains than in the parent strain. Preincubation of the cells with carbonyl cyanide m-chlorophenylhydrazone, however, completely abolished this difference. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of outer membrane preparations from both mutant strains showed overexpression of two proteins of 55 and 39 kDa which were absent from the outer membranes of the wild-type strain. These results indicate that in C. jejuni 34PEFr and 34CTXr, multidrug resistance is associated with an efflux system with a broad specificity.
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