ArticleJournal of clinical pathology1995
Serological reactivity against cyst and tachyzoite antigens of Toxoplasma gondii determined by FAST-ELISA.
Article in Journal of clinical pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Toxoplasma gondii-positive human sera recognise intracellular tachyzoites and bradyzoites with diverse patterns of immunoreactivity.International journal for parasitology · 2018Article
- Design of Indigenous ELISA Using Tachyzoites from the RH Strain ofJundishapur journal of microbiology · 2016Article
- A Purification Method for Enrichment of the Toxoplasma gondii Cyst Wall.Journal of neuroparasitology · 2010Article
- Aqueous humor and serum immunoblotting for immunoglobulin types G, A, M, and E in cases of human ocular toxoplasmosis.Journal of clinical microbiology · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo obtain quantitative data on the human serological response to Toxoplasma gondii tachyzoite and bradyzoite antigens.
methodsSerum samples from 30 patients who had positive antibody titres against T gondii and from 14 who were seronegative, together with sequential serum samples from four infected individuals, were screened by FAST-ELISA.
resultsSerum samples from the 30 seropositive patients showed high IgG and IgM titres against the T gondii tachyzoite antigen but very low responses to cyst antigen. This result was borne out in sequential serum samples from patients with toxoplasmosis.
conclusionAntibody recognition of the cystic stage of T gondii is low, implying that either this stage is poorly immunogenic or that the antigen load is low.
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Registered trials
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