ReviewJournal of clinical immunology1995
Role of apoptosis in HIV disease pathogenesis.
Review in Journal of clinical immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 78 citations in OpenAlex.
- An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation?International journal of molecular sciences · 2021Review
- Review
- Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.Cell death & disease · 2015Article
- Cytosolic phospholipase A2 regulates alcohol-mediated astrocyte inflammatory responses in HIV-associated neurocognitive disorders.Cell death discovery · 2015Article
- Role of common gamma chain utilizing cytokines for immune reconstitution in HIV infection.Immunologic research · 2007Article
- Molecular interactions of human immunodeficiency virus type 1 with primary human oral keratinocytes.Journal of virology · 2005Article
- Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.Cancer science · 2003Article
- T cell activation, apoptosis and cytokine dysregulation in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB).Clinical and experimental immunology · 2000Article
- Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2.Journal of clinical immunology · 1999Article
- Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosis.Journal of virology · 1998Article
- The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.The Journal of clinical investigation · 1998Article
- Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes.Immunology · 1997Article
- Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor.The Journal of experimental medicine · 1997Article
- Programmed cell death (apoptosis) in cord blood lymphocytes.Journal of clinical immunology · 1997Article
- T helper cell activation and human retroviral pathogenesis.Microbiological reviews · 1996Review
- Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Apoptosis induced by HIV-1 infection of the central nervous system.The Journal of clinical investigation · 1996Article
- Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.Microbiological reviews · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.