ArticleGut1995
Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Proton pump inhibitors for functional dyspepsia.The Cochrane database of systematic reviews · 2017Pooled it
- Proton pump inhibitors for functional dyspepsia.The Cochrane database of systematic reviews · 2017Pooled it
- Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes.European journal of clinical pharmacology · 2012Trial
- Trial
- Eradicating Helicobacter pylori reduces hypergastrinaemia during long-term omeprazole treatment.Gut · 1998Trial
- Trial
- The effect of orally administered ranitidine and once-daily or twice-daily orally administered omeprazole on intragastric pH in cats.Journal of veterinary internal medicineTrial
- Effect of acid-reducing agents on clinical relapse in ulcerative colitis with pH-dependent-released 5-aminosalicylic acid: a multicenter retrospective study in Japan.Intestinal research · 2021Article
- Proton pump inhibitors and risk of periampullary cancers--A nested case-control study.International journal of cancer · 2016Article
- High Recurrence Rate of Idiopathic Peptic Ulcers in Long-Term Follow-up.Gut and liver · 2013Article
- Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors.World journal of gastroenterology · 2008Article
- The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs.Digestive diseases and sciences · 2008Article
- Validation of the blood quininium resin test for assessing gastric hypochlorhydria.Digestive diseases and sciences · 2006Article
- Article
- Inhibitory potency of twice-a-day omeprazole on gastric acidity is enhanced by eradication of H. pylori in duodenal ulcer patients.Digestive diseases and sciences · 2003Article
- Gastroesophageal reflux and Helicobacter pylori: a review.World journal of gastroenterology · 2000Article
- Review
- Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole.Gut · 1999Article
- Review
- [1997 gastroenterology update--I].Medizinische Klinik (Munich, Germany : 1983) · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been shown that omeprazole treatment produces higher intragastric pH values in Helicobacter pylori positive subjects than in H pylori negative subjects. This study aimed to investigate the effect of curing H pylori on the intragastric pH in both the presence and absence of omeprazole therapy. Twenty four hour intragastric pH recordings were performed before and after a one week course of omeprazole (20 mg once daily) in 18 H pylori positive subjects and were repeated after the infection had been cured. In the absence of omeprazole, the total 24 hour pH values before cure did not differ from those afterwards. During omeprazole treatment the 24 hour pH values were much higher before (median (95% CI) 5.4: 4.3, 6.0), than after cure of infection (3.6: 2.1, 4.4; p < 0.001). The omeprazole induced fall in H+ activity before cure of H pylori did not, however, differ from that afterwards. It is concluded that the apparently greater antisecretory effect of omeprazole during H pylori infection may be a result of the production of acid neutralising compounds by the H pylori. Although a direct interaction between H pylori and omeprazole cannot be excluded, it seems unlikely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.