ArticleGenetics1995
Heteroduplex DNA formation and homolog pairing in yeast meiotic mutants.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 103 citations in OpenAlex.
- Meiosis in budding yeast.Genetics · 2023Article
- Review
- Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes.PLoS genetics · 2020Article
- Flanking heterozygosity influences the relative probability of different base substitutions in humans.Royal Society open science · 2019Article
- Article
- Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.Science (New York, N.Y.) · 2017Article
- Article
- Article
- Variation in heterozygosity predicts variation in human substitution rates between populations, individuals and genomic regions.PloS one · 2013Article
- Meiotic development in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- Multiple opposing constraints govern chromosome interactions during meiosis.PLoS genetics · 2013Article
- Article
- Finding the correct partner: the meiotic courtship.Scientifica · 2012Review
- Evidence that MEK1 positively promotes interhomologue double-strand break repair.Nucleic acids research · 2010Article
- Temporal characterization of homology-independent centromere coupling in meiotic prophase.PloS one · 2010Article
- Article
- Sites of recombination are local determinants of meiotic homolog pairing in Saccharomyces cerevisiae.Genetics · 2008Article
- Prelude to a division.Annual review of cell and developmental biology · 2008Review
- A novel nonnull ZIP1 allele triggers meiotic arrest with synapsed chromosomes in Saccharomyces cerevisiae.Genetics · 2007Article
- Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae.Genetics · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies of Saccharomyces cerevisiae have identified several meiosis-specific genes whose products are required for wild-type levels of meiotic recombination and for normal synaptonemal complex (SC) formation. Several of these mutants were examined in a physical assay designed to detect heteroduplex DNA (hDNA) intermediates in meiotic recombination. hDNA was not detected in the rec102, mei4 and hop1 mutants; it was observed at reduced levels in red1, mek1 and mer1 strains and at greater than the wild-type level in zip1. These results indicate that the REC102, MEI4, HOP1, RED1, MEK1 and MER1 gene products act before hDNA formation in the meiotic recombination pathway, whereas ZIP1 acts later. The same mutants assayed for hDNA formation were monitored for meiotic chromosome pairing by in situ hybridization of chromosome-specific DNA probes to spread meiotic nuclei. Homolog pairing occurs at wild-type levels in the zip1 and mek1 mutants, but is substantially reduced in mei4, rec102, hop1, red1 and mer1 strains. Even mutants that fail to recombine or to make any SC or SC precursors undergo a significant amount of meiotic chromosome pairing. The in situ hybridization procedure revealed defects in meiotic chromatin condensation in mer1, red1 and hop1 strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.