ArticleGenetics1995
Islands of complex DNA are widespread in Drosophila centric heterochromatin.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 118 citations in OpenAlex.
- Centromere structure and function: lessons from Drosophila.Genetics · 2023Article
- Islands of retroelements are major components of Drosophila centromeres.PLoS biology · 2019Article
- Simple and Complex Centromeric Satellites inGenetics · 2018Article
- Single-molecule sequencing resolves the detailed structure of complex satellite DNA loci inGenome research · 2017Article
- Identification and diversity of functional centromere satellites in the wild rice species Oryza brachyantha.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Novel simple sequence repeats (SSRs) detected by ND-FISH in heterochromatin of Drosophila melanogaster.BMC genomics · 2011Article
- Healing of euchromatic chromosome breaks by efficient de novo telomere addition in Drosophila melanogaster.Genetics · 2010Article
- Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila.PLoS biology · 2009Article
- Article
- Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation.Genetics · 2005Article
- Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.Genes & development · 2004Article
- A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Chromosoma · 2004Article
- Genetics of P-element transposition into Drosophila melanogaster centric heterochromatin.Genetics · 2003Article
- Sequence analysis of a functional Drosophila centromere.Genome research · 2003Article
- Various organizations of the complex repeats in vole sex chromosome heterochromatin.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Article
- Remarkable compartmentalization of transposable elements and pseudogenes in the heterochromatin of the Tetraodon nigroviridis genome.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Efficient recovery of centric heterochromatin P-element insertions in Drosophila melanogaster.Genetics · 2002Article
- Modifiers of terminal deficiency-associated position effect variegation in Drosophila.Genetics · 2002Article
- Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.Genome biology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Heterochromatin is a ubiquitous yet poorly understood component of multicellular eukaryotic genomes. Major gaps exist in our knowledge of the nature and overall organization of DNA sequences present in heterochromatin. We have investigated the molecular structure of the 1 Mb of centric heterochromatin in the Drosophila minichromosome Dp1187. A genetic screen of irradiated minichromosomes yielded rearranged derivatives of Dp1187 whose structures were determined by pulsed-field Southern analysis and PCR. Three Dp1187 deletion derivatives and an inversion had one breakpoint in the euchromatin and one in the heterochromatin, providing direct molecular access to previously inaccessible parts of the heterochromatin. End-probed pulsed-field restriction mapping revealed the presence of at least three "islands" of complex DNA, Tahiti, Moorea, and Bora Bora, constituting approximately one half of the Dp1187 heterochromatin. Pulsed-field Southern analysis demonstrated that Drosophila heterochromatin in general is composed of alternating blocks of complex DNA and simple satellite DNA. Cloning and sequencing of a small part of one island, Tahiti, demonstrated the presence of a retroposon. The implications of these findings to heterochromatin structure and function are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.