ArticleGenetics1995
Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- In vivo analysis of Drosophila SU(Z)12 function.Molecular genetics and genomics : MGG · 2008Article
- Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA.Genes & development · 2003Article
- A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span.Genetics · 2002Article
- Non-coding RNAs: the architects of eukaryotic complexity.EMBO reports · 2001Article
- Review
- The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste.Genes & development · 2000Article
- A reexamination of spreading of position-effect variegation in the white-roughest region of Drosophila melanogaster.Genetics · 2000Article
- Article
- A proline-rich region in the Zeste protein essential for transvection and white repression by Zeste.Genetics · 1998Article
- Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation.Nucleic acids research · 1997Review
- Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster.Genetics · 1997Article
- Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.American journal of human genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence is presented demonstrating that mutations of zeste, particularly the null state, are strong recessive enhancers of position-effect variegation (PEV) for the white, roughest and Notch loci. The zeste locus encodes a DNA-binding protein that acts as a transcription factor and mediates transvection phenomena at several loci. Its involvement with these seemingly diverse phenomena suggests that the normal zeste product functions in the decondensation of chromatin. A model is presented proposing that zeste is important for opening and stabilizing domains of chromatin, a step in gene determination and the establishment of cell memory. It postulates that chromatin domains that have been structurally modified by chromosomal rearrangement or by insertion of transposable elements are particularly sensitive to the absence or modification of the zeste protein. Such a view unifies the role of zeste in transcription, transvection and PEV.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.