ArticleGenetics1995
Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology.Nature structural & molecular biology · 2023Review
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
- Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.Insect biochemistry and molecular biology · 2020Article
- RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum.Scientific reports · 2016Article
- Model systems for studying cellular mechanisms of SCN1A-related epilepsy.Journal of neurophysiology · 2016Review
- Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Experimental neurology · 2015Review
- A single crossing-over event in voltage-sensitive Na+ channel genes may cause critical failure of dengue mosquito control by insecticides.PLoS neglected tropical diseases · 2014Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Multiple sodium channel variants in the mosquito Culex quinquefasciatus.International journal of biological sciences · 2012Article
- Molecular characterization and functional expression of the DSC1 channel.Insect biochemistry and molecular biology · 2011Article
- Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.Journal of neurophysiology · 2009Article
- A novel Na+ channel splice form contributes to the regulation of an androgen-dependent social signal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Use of non-mammalian alternative models for neurotoxicological study.Neurotoxicology · 2008Review
- Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster.Insect biochemistry and molecular biology · 2008Article
- Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Insect sodium channels and insecticide resistance.Invertebrate neuroscience : IN · 2007Review
- Complex alternative splicing.Advances in experimental medicine and biology · 2007Review
- The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA.Molecular and cellular biology · 2005Article
- Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- RNA editing generates tissue-specific sodium channels with distinct gating properties.The Journal of biological chemistry · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We cloned genomic DNA corresponding to the Drosophila virilis homologue of para, a gene encoding a sodium channel alpha-subunit, and obtained many partial cDNA clones from embryos and adults. Para protein has been well conserved, and the optional elements at six different sites of alternative splicing in D. melanogaster are present in D. virilis, in addition to one new optional exon. Among 31 different splice-types observed in D. virilis, the stage-specific pattern of alternative splicing seen in D. melanogaster is also conserved. Comparison of genomic DNA sequence revealed three aspects that vary between alternatively and constitutively used exon sequences. Sixteen short blocks (10-75 bp), the only recognizably conserved intron sequence, were disproportionately associated with alternatively used splice sites. Silent site substitutions were found much less frequently in alternative than constitutive exon elements, and the degree of match to the Drosophila splice site consensus tended to be lower at less frequently selected alternative splice junctions. This study shows that the developmentally regulated variability of para products is highly conserved and therefore likely to be of functional significance and suggests that a variety of different sequence-dependent mechanisms may regulate this pattern of alternative splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.