Evidence map›Paper›PMID 8536961›Full record

ArticleGenetics1995

Species-specific and mating type-specific DNA regions adjacent to mating type idiomorphs in the genus Neurospora.

T A Randall, R L Metzenberg

Abstract read
In one paragraph

Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evolution of the fungal self-fertile reproductive life style from self-sterile ancestors.Proceedings of the National Academy of Sciences of the United States of America · 1999
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

T A RandallDepartment of Biomolecular Chemistry, University of Wisconsin, Madison 53706, USA.
R L Metzenberg

Funding

THE GENETIC CONTROL OF PROTEIN SYNTHESISR01GM008995 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI METZENBERG, ROBERT L · 1985 to 1988
–
THE GENETIC CONTROL OF PROTEIN SYNTHESISR37GM008995 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI METZENBERG, ROBERT L · 1989 to 1998
–
NIGMS NIH HHS GM-08995
6 · The paper itself

Abstract

Mating type idiomorphs control mating and subsequent sexual development in Neurospora crassa and were previously shown to be well conserved in other Neurospora species. The centromere-proximal flanks of the A and a idiomorphs, but not the distal flanks from representative heterothallic, pseudohomothallic, and homothallic Neurospora species contain apparent species-specific and/or mating type-specific sequences adjacent to the well-conserved idiomorphs. The variable flank is bordered by regions that are highly homologous in all species. The sequence of approximately 1 kb immediately flanking the conserved idiomorphs of each species was determined. Sequence identity between species ranged from 20% (essentially unrelated) to > 90%. By contrast, the mt-A1 gene shows 88-98% identity. Sequence and hybridization data also show that the centromere-proximal flanks are very different between the two mating types for N. intermedia, N. discreta, and N. tetrasperma, but not for N. sitophila and N. crassa. The data suggest a close evolutionary relationship between several of the species; this is suppported by phylogenetic analysis of their respective mt-A1 genes. The origin of the variable regions adjacent to the evolutionarily conserved mating type idiomorphs is unknown.

Indexed as

DNA, FungalGenes, FungalGenes, Mating Type, FungalBase SequenceBiological EvolutionCentromereChromosomes, FungalMolecular Sequence DataNeurosporaNucleic Acid HybridizationSpecies SpecificityDNA, Fungal

Identifiers

PMID8536961
PMCPMC1206711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.