ArticleDigestive diseases and sciences1995
Morphometric analysis of intestinal mucins under different dietary conditions and gut flora in rats.
Article in Digestive diseases and sciences, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 98 citations in OpenAlex.
- Article
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- Roles of Microbiota in Cancer: From Tumor Development to Treatment.Journal of oncology · 2022Review
- Chicken Coccidiosis: From the Parasite Lifecycle to Control of the Disease.Frontiers in veterinary science · 2021Review
- Leuconostoc mesenteroides subsp. mesenteroides SD23 Prevents Metabolic Dysfunction Associated with High-Fat Diet-Induced Obesity in Male Mice.Probiotics and antimicrobial proteins · 2020Article
- Is the colon mucosa affected by ten days of gastric restriction in an animal model?Acta cirurgica brasileira · 2019Article
- Effects of Different Diets on Microbiota in The Small Intestine Mucus and Weight Regulation in Rats.Scientific reports · 2019Article
- The impact of synbiotic administration through in ovo technology on the microstructure of a broiler chicken small intestine tissue on the 1Journal of animal science and biotechnology · 2017Article
- Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia.MicrobiologyOpen · 2016Article
- Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice.BMC gastroenterology · 2015Article
- Metronidazole or Cotrimoxazole therapy is associated with a decrease in intestinal bioavailability of common antiretroviral drugs.PloS one · 2014Article
- Article
- Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats.PloS one · 2011Article
- On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa.PloS one · 2011Article
- The role of the intestine in the pathophysiology and management of severe acute pancreatitis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2003Article
- Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon.Digestive diseases and sciences · 2001Article
- Dietary fibre and intestinal microflora: effects on intestinal morphometry and crypt branching.Gut · 1998Article
- Morphological characteristics, epithelial cell proliferation, and crypt fission in cecum and colon of growing pigs.Digestive diseases and sciences · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidation of the mechanisms that alter the biosynthesis, turnover, and degradation of intestinal mucins is relevant to the understanding of both the normal gut ecosystem and various intestinal diseases. In this study image analysis was used to quantify the effects of diet and microbial flora on the mucin composition of goblet and deep crypt cells, the number and volume density of mucin-containing cells, and the staining density of their stored mucins in the small and large intestine of germ-free and conventionally maintained rats fed two different diets. One was a coarsely ground commercial rodent diet containing crude fiber of cereal origin and the other a purified diet composed of finely powdered ingredients, including cellulose as a source of fiber. The changes in mucin production were also analyzed in germ-free rats colonized with a human flora. Feeding a commercial diet reduced the volume density of cells containing neutral and sulfomucins in the jejunum of conventional rats and the staining density of neutral and acidic mucins in the germ-free rats. Both rat and human floras reduced the number of cells containing acidic and sulfomucins and the staining density of neutral mucins in the small intestine of animals fed on a purified diet. However, inoculation of human flora increased the staining density of stored neutral and sulfated mucins in the cells of the large intestine. The results demonstrate that the dietary changes are influential in modifying the amount and proportion of mucins in the small intestine and the microbial flora in the large intestine.
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