Evidence map›Paper›PMID 8536073›Full record

ArticleHistochemistry and cell biology1995

Lectin binding defines and differentiates M-cells in mouse small intestine and caecum.

M A Clark, M A Jepson, B H Hirst

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 41 citations in OpenAlex.

  1. Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2015
    Review
  2. Article
  3. Article
  4. Intestinal M cells: the fallible sentinels?World journal of gastroenterology · 2007
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Targeting to intestinal M cells.Journal of anatomy · 1996
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M A ClarkDepartment of Physiological Sciences, University of Newcastle upon Tyne, Medical School, UK.
M A Jepson
B H Hirst
Newcastle University · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

M-cell surface glycoconjugate expression was investigated by applying a panel of lectins to whole fixed mouse Peyer's and caecal patches. While the majority of lectins failed to identify mouse M-cells, the lectin Euonymus europaeus differentially stained the surface of M-cells in both mouse Peyer's and caecal patches, and the lectins Ulex europaeus II and Bandeiraea simplicifolia I isolectin B4 identified M-cells in the Peyer's and caecal patch follicle associated epithelium, respectively. These three mouse M-cell markers failed to identify rat and rabbit Peyer's patch M-cells, although both Euonymus europaeus and Ulex europaeus II differentially stained M-cells in the periphery of rabbit caecal patch domes. These site and species related variations in M-cell surface glycoconjugate expression may reflect the local microorganism populations and will have important implications if orally delivered vaccines and drugs are to be targeted to M-cells via their surface glycoconjugates.

Indexed as

AnimalsCecumEpithelial CellsEpitheliumHistocytochemistryIntestinal MucosaIntestine, SmallLectinsMaleMiceMice, Inbred BALB COrgan SpecificityPeyer's PatchesRabbitsRatsRats, WistarLectins

Identifiers

PMID8536073
OpenAlexW1969635870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.