ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
Mapping of the SLA complex class III region by pulsed field gel electrophoresis.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 8 citations in OpenAlex.
- Application of three different methods to analyse fibre-FISH results obtained using four lambda clones from the porcine MHC III region.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1997Article
- A detailed physical map of the porcine major histocompatibility complex (MHC) class III region: comparison with human and mouse MHC class III regions.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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3 authors at 2 institutions in 1 country.
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Abstract
The fine order of genes in the class III region of the swine major histocompatibility complex (MHC), the SLA complex, was examined by pulsed field gel electrophoresis (PFGE) and Southern blot analysis. Four genes, C2, HSP70, TNF alpha, and CYP21, were analyzed. The CYP21, C2, and HSP70 genes were all located within a 200-kb NotI fragment. The C2, HSP70, and TNF alpha genes cohybridized to a 420-kb SalI fragment. The TNF alpha gene is linked to the class I region by a 390-kb NotI fragment. Combined with a previous study from our lab, the order of genes in the SLA complex is class II-class III [(CYP21/C4)-(Bf/C2/HSP70)-TNF alpha]-class I. The size of the class III region from CYP21 to TNF alpha is estimated to be 500 kb. This size and the order of the genes in the swine class III region are similar to those of human, mouse, goat, and rabbit, which confirms the high conservation of class III gene organization across species.
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