ReviewDrugs & aging1995
Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis.
Review in Drugs & aging, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00328601 (Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- Topical capsaicin (low concentration) for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Topical capsaicin for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2009Pooled it
- Systematic review of topical capsaicin for the treatment of chronic pain.BMJ (Clinical research ed.) · 2004Pooled it
- Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.British journal of clinical pharmacology · 2000Trial
- Diabetic Neuropathy: An Overview of Molecular Pathways and Protective Mechanisms of Phytobioactives.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Article
- Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process.Molecular medicine reports · 2023Article
- Issues and challenges in diabetic neuropathy management: A narrative review.World journal of diabetes · 2023Review
- Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli.Bioengineering & translational medicine · 2023Article
- TRP Channels as Sensors of Aldehyde and Oxidative Stress.Biomolecules · 2021Review
- Cross-Species Comparison of Fruit-Metabolomics to Elucidate Metabolic Regulation of Fruit Polyphenolics Among Solanaceous Crops.Metabolites · 2020Article
- Integrative Approaches in Pediatric Palliative Care.Children (Basel, Switzerland) · 2018Article
- Bottlenecks in the development of topical analgesics: molecule, formulation, dose-finding, and phase III design.Journal of pain research · 2017Review
- Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation.International journal of nanomedicine · 2017Article
- Pharmacotherapies in Geriatric Chronic Pain Management.Clinics in geriatric medicine · 2016Review
- A Mechanism-Based Approach to the Management of Osteoarthritis Pain.Current osteoporosis reports · 2015Review
- Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications.Pain and therapy · 2015Article
- Amitriptyline 2% cream vs. capsaicin 0.75% cream in the treatment of painful diabetic neuropathy (Double blind, randomized clinical trial of efficacy and safety).Iranian journal of pharmaceutical research : IJPR · 2015Article
- Capsaicinoids in the treatment of neuropathic pain: a review.Therapeutic advances in neurological disorders · 2014Review
- Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin.Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsaicin, the active principle of hot chili pepper, is thought to selectively stimulate unmyelinated C fibre afferent neurons and cause the release of substance P. Prolonged application of capsaicin reversibly depletes stores of substance P, and possibly other neurotransmitters, from sensory nerve endings. This reduces or abolishes the transmission of painful stimuli from the peripheral nerve fibres to the higher centres. In clinical studies of patients with post-hepatic neuralgia, diabetic neuropathy or osteoarthritis, adjunctive therapy with topical capsaicin achieved better relief than its vehicle in most studies. In a single trial, topical capsaicin in demonstrated similar efficacy to oral amitriptyline in patients with diabetic neuropathy. Topical capsaicin is not associated with any severe systemic adverse effects. However, stinging and burning, particularly during the first week of therapy, is reported by many patients. Topical capsaicin merits consideration as adjuvant therapy in conditions such as post-herpetic neuralgia, diabetic neuropathy and osteoarthritis, where the pain can be chronic and difficult to treat.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.