ArticleMolecular biology of the cell1995
The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans.Nature communications · 2023Article
- Evolution of sex determination in crustaceans.Marine life science & technology · 2023Review
- Transcriptional profiles in Strongyloides stercoralis males reveal deviations from the Caenorhabditis sex determination model.Scientific reports · 2021Article
- Hemimetabolous insects elucidate the origin of sexual development via alternative splicing.eLife · 2019Article
- Tissue-Specific Functions ofG3 (Bethesda, Md.) · 2018Article
- Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging inGenetics · 2017Article
- Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.Biochemistry · 2017Article
- Communication between oocytes and somatic cells regulates volatile pheromone production in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.The Journal of biological chemistry · 2013Article
- Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes.PLoS genetics · 2013Article
- SPE-44 implements sperm cell fate.PLoS genetics · 2012Article
- The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans.Molecular and cellular biology · 2010Article
- Article
- SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans.Developmental biology · 2008Article
- Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Comparative genetics of sex determination: masculinizing mutations in Caenorhabditis briggsae.Genetics · 2008Article
- A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.Developmental cell · 2007Article
- Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- Conspecific and interspecific interactions between the FEM-2 and the FEM-3 sex-determining proteins despite rapid sequence divergence.Journal of molecular evolution · 2006Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The genetic and molecular analysis of genes involved in the regulation of sex determination in Caenorhabditis elegans suggests that the gene fem-2 plays an important role in regulating a pathway transducing a non-cell-autonomous signal to a nuclear transcription factor. The wild-type fem-2 gene was cloned by identifying sequences from the C. elegans physical map that could restore normal Fem-2 function to homozygous mutant fem-2 transgenic animals. cDNA sequences mapping to the minimal rescuing region correspond to an open reading frame with a sequence similar to protein phosphatase 2C enzymes from systems as diverse as yeast, humans, and plants, but the alignments suggest that FEM-2 falls into a separate class of proteins than the canonical homologues. Several fem-2 mutant alleles were sequenced, and the mutations are predicted to cause protein changes consistent with their observed phenotypes, such as missense mutations in conditional alleles, and a nonsense mutation in a predicted null allele. This is the first evidence implicating phosphorylation and/or dephosphorylation as a control mechanism in C. elegans sex determination.
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