ArticleAmerican journal of human genetics1995
Evolution of haplotypes at the DRD2 locus.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.Translational psychiatry · 2016Pooled it
- Evaluation of microhaplotypes in forensic kinship analysis from a Swedish population perspective.International journal of legal medicine · 2021Article
- The psychological and genetic factors of the addictive behaviors (PGA) study.International journal of methods in psychiatric research · 2019Article
- An historical perspective on "The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus".Human genetics · 2014Review
- Article
- Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence.PloS one · 2013Article
- Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity.PloS one · 2013Article
- PharmGKB summary: dopamine receptor D2.Pharmacogenetics and genomics · 2011Article
- Haplotype diversity and linkage disequilibrium at the DRD2 locus among the tribes of western and southern regions of India.Indian journal of human genetics · 2010Article
- Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.Behavioral and brain functions : BBF · 2010Article
- Cortical NMDA receptor expression in human chronic alcoholism: influence of the TaqIA allele of ANKK1.Neurochemical research · 2009Article
- Haplotype frequencies at the DRD2 locus in populations of the East European Plain.BMC genetics · 2009Article
- Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study.Occupational and environmental medicine · 2007Article
- Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence.Journal of psychiatry & neuroscience : JPN · 2007Article
- Relationship between adverse effects of antipsychotic treatment and dopamine D(2) receptor polymorphisms in patients with schizophrenia.Molecular psychiatry · 2002Article
- Localization of a small genomic region associated with elevated ACE.American journal of human genetics · 2000Article
- Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.American journal of human genetics · 2000Article
- Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations.American journal of human genetics · 2000Article
- Effects of worldwide population subdivision on ALDH2 linkage disequilibrium.Genome research · 1999Article
- Evidence for effective suppression of recombination in the chromosome 17q21 segment spanning RNU2-BRCA1.American journal of human genetics · 1999Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
We present here the first evolutionary perspective on haplotypes at DRD2, the locus for the dopamine D2 receptor. The dopamine D2 receptor plays a critical role in the functioning of many neural circuits in the human brain. If functionally relevant variation at the DRD2 locus exists, understanding the evolution of haplotypes on the basis of polymorphic sites encompassing the gene should provide a powerful framework for identifying that variation. Three DRD2 polymorphisms (TaqI "A" and "B" RFLPs and the (CA)n short tandem repeat polymorphic in all the populations studied, and they display strong and significant linkage disequilibria with each other. The common haplotypes for the two TaqI RFLPs are separately derived from the ancestral haplotype but predate the spread of modern humans around the world. The knowledge of how the various haplotypes have evolved, the allele frequencies of the haplotypes in human populations, and the physical relationships of the polymorphisms to each other and to the functional parts of the gene should now allow proper design and interpretation of association studies.
Indexed as
Identifiers
8533775PMC1801414W1574767866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.