ArticleAmerican journal of human genetics1995
Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.Human immunology · 2008Pooled it
- BDNF gene is a risk factor for schizophrenia in a Scottish population.Molecular psychiatry · 2005Trial
- HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors.Frontiers in immunology · 2025Article
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- HLA allele and haplotype frequencies of registered stem cell donors in Chile.Frontiers in immunology · 2023Article
- High Resolution HLA ∼A, ∼B, ∼C, ∼DRB1, ∼DQA1, and ∼DQB1 Diversity in South African Populations.Frontiers in genetics · 2022Article
- Common and well-documented HLA alleles of German stem cell donors by haplotype frequency estimation.HLA · 2018Article
- Simulation shows that HLA-matched stem cell donors can remain unidentified in donor searches.Scientific reports · 2016Article
- A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer.Immunogenetics · 2012Article
- Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.PloS one · 2012Article
- Analytical methods for immunogenetic population data.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.The Journal of experimental medicine · 2006Article
- HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.Genes and immunity · 2004Article
- Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study.Psychopharmacology · 2004Article
- Coeliac disease patients carry conserved HLA-DR3-DQ2 haplotypes revealed by association of TNF alleles.Immunogenetics · 2003Article
- Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.Genes and immunity · 2003Article
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.American journal of human genetics · 2002Article
- Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA.Genes and immunity · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Disequilibrium between genetic markers is expected to decline monotonically with recombinational map distance. We present evidence from the HLA class II region that seems to violate this principle. Pairwise disequilibrium values were calculated from six loci ranging in physical separation from 15 kb to 550 kb. The histocompatibility loci DRB1, DQA1, and DQB1, located on the distal end of the class II region, behave as a single evolutionary unit within which extremely high linkage disequilibrium exists. Lower but still significant levels of disequilibrium are present between these loci and DPB1, located at the proximal edge of the HLA complex. The peptide-transporter loci TAP1 and TAP2, located in the intervening region, reveal no disequilibrium with each other and low or negligible disequilibrium with the flanking loci. The action of two genetic process is required to account for this phenomenon: a recombinational hotspot operating between TAP1 and TAP2, to eliminate disequilibrium between these loci, and at the same time selection operating on particular combinations of alleles across the DR-DP region, to create disequilibrium in the favored haplotypes. The forces producing the patterns of disequilibrium observed here have implications for the mapping of train loci and disease genes: markers of TAP1, for example, would give a false impression as to the influence of DPB1 on a trait known to be associated with DQB1.
Indexed as
Identifiers
8533774PMC1801434W1902872325What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.