ArticleAmerican journal of human genetics1995
Human beta-globin gene polymorphisms characterized in DNA extracted from ancient bones 12,000 years old.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Introduction. Ancient DNA: the first three decades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- A search for β thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans.Blood cells, molecules & diseases · 2012Article
- Y chromosomes of prehistoric people along the Yangtze River.Human genetics · 2007Article
- Reply to Stoneking: ancient DNA--how do you really know when you have it?American journal of human genetics · 1997Article
- The retrieval of ancient human DNA sequences.American journal of human genetics · 1996Article
- Ancient DNA: how do you know when you have it and what can you do with it?American journal of human genetics · 1995Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analyzing the nuclear DNA from ancient human bones is an essential step to the understanding of genetic diversity in current populations, provided that such systematic studies are experimentally feasible. This article reports the successful extraction and amplification of nuclear DNA from the beta-globin region from 5 of 10 bone specimens up to 12,000 years old. These have been typed for beta-globin frameworks by sequencing through two variable positions and for a polymorphic (AT) chi (T) gamma microsatellite 500 bp upstream of the beta-globin gene. These specimens of human remains are somewhat older than those analyzed in previous nuclear gene sequencing reports and considerably older than those used to study high-copy-number human mtDNA. These results show that the systematic study of nuclear DNA polymorphisms of ancient populations is feasible.
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Registered trials
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