ArticleNucleic acids research1995
Homodimerization of the human U1 snRNP-specific protein C.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes.Frontiers in molecular biosciences · 2021Article
- RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.Molecular and cellular biology · 2012Article
- RNA editing in Trypanosoma brucei requires three different editosomes.Molecular and cellular biology · 2008Article
- An essential RNase III insertion editing endonuclease in Trypanosoma brucei.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Comparative analysis of editosome proteins in trypanosomatids.Nucleic acids research · 2003Article
- The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.The EMBO journal · 2002Article
- Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles.RNA (New York, N.Y.) · 2001Article
- Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.Molecular and cellular biology · 2000Article
- WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Identification and characterization of a yeast homolog of U1 snRNP-specific protein C.The EMBO journal · 1997Article
- In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes.Nucleic acids research · 1996Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The U1 snRNP-specific protein C contains an N-terminal zinc finger-like CH motif which is required for the binding of the U1C protein to the U1 snRNP particle. Recently a similar motif was reported to be essential for in vivo homodimerization of the yeast splicing factor PRP9. In the present study we demonstrate that the human U1C protein is able to form homodimers as well. U1C homodimers are found when (i) the human U1C protein is expressed in Escherichia coli, (ii) immunoprecipitations with anti-U1C antibodies are performed on in vitro translated U1C, and when (iii) the yeast two hybrid system is used. Analyses of mutant U1C proteins in an in vitro dimerization assay and the yeast two hybrid system revealed that amino acids within the CH motif, i.e. between positions 22 and 30, are required for homodimerization.
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