ReviewMicrobiological reviews1995
Production and function of cytokines in natural and acquired immunity to Candida albicans infection.
Review in Microbiological reviews, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 135 citations in OpenAlex.
- Advances in Fungal Infection Research: From Novel Diagnostics to Innovative Therapeutics.Journal of fungi (Basel, Switzerland) · 2025Article
- Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis.Communications biology · 2021Article
- Anti-Inflammatory Effects of Vitamin E in Response toMicroorganisms · 2020Article
- Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Importance ofFrontiers in cellular and infection microbiology · 2019Article
- Candidal Infection of the Gingiva Mimicking Desquamative Gingivitis: A Case Report.Journal of clinical and diagnostic research : JCDR · 2016Article
- The Effects of Opium Addiction on the Immune System Function in Patients with Fungal Infection.Addiction & health · 2016Article
- Mycobiota in gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2015Review
- Protection from systemic Candida albicans infection by inactivation of the Sts phosphatases.Infection and immunity · 2015Article
- The Effect of Cooled Perches on Immunological Parameters of Caged White Leghorn Hens during the Hot Summer Months.PloS one · 2015Article
- Early expression of local cytokines during systemicBiomedical reports · 2014Article
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.The Journal of clinical and aesthetic dermatology · 2012Article
- Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.PloS one · 2012Article
- A review of the ultrastructural features of superficial candidiasis.Mycopathologia · 2011Review
- Impairment of host defense against disseminated candidiasis in mice overexpressing GATA-3.Infection and immunity · 2010Article
- Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model.Infection and immunity · 2007Article
- Drosophila melanogaster Thor and response to Candida albicans infection.Eukaryotic cell · 2007Article
- The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications.Infection and immunity · 2007Article
- Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans.Infection and immunity · 2005Article
- Genetic analysis of innate immunity in resistance to Candida albicans.Genes and immunity · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host resistance against infections caused by the yeast Candida albicans is mediated predominantly by polymorphonuclear leukocytes and macrophages. Antigens of Candida stimulate lymphocyte proliferation and cytokine synthesis, and in both humans and mice, these cytokines enhance the candidacidal functions of the phagocytic cells. In systemic candidiasis in mice, cytokine production has been found to be a function of the CD4+ T helper (Th) cells. The Th1 subset of these cells, characterized by the production of gamma interferon and interleukin-2, is associated with macrophage activation and enhanced resistance against reinfection, whereas the Th2 subset, which produces interleukins-4, -6, and -10, is linked to the development of chronic disease. However, other models have generated divergent data. Mucosal infection generally elicits Th1-type cytokine responses and protection from systemic challenge, and identification of cytokine mRNA present in infected tissues of mice that develop mild or severe lesions does not show pure Th1- or Th2-type responses. Furthermore, antigens of C. albicans, mannan in particular, can induce suppressor cells that modulate both specific and nonspecific cellular and humoral immune responses, and there is an emerging body of evidence that molecular mimicry may affect the efficiency of anti-Candida responses within defined genetic contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.