A sublocus of the multicopy microsatellite marker CMS1 maps proximal to spinal muscular atrophy (SMA) as shown by recombinant analysis.

G van der Steege, J M Cobben, J Osinga, H Scheffer, G J van Ommen, C H Buys

Abstract read

In one paragraph

Article in Human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A recombination event occurring within two complex 5q13.1 microsatellite repeat polymorphisms suggests a telomeric mapping of spinal muscular atrophy.Human genetics · 1995
Article

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

G van der SteegeDepartment of Medical Genetics, University of Groningen, The Netherlands.

J M Cobben

J Osinga

H Scheffer

G J van Ommen

C H Buys

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.

Indexed as

Chromosome MappingDNA, SatelliteFemaleHumansMaleMuscular Atrophy, SpinalPolymerase Chain ReactionDNA, Satellite

Identifiers

PMID8530008

DOI10.1007/BF00197416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.