ArticleChromosoma1995
Chromosome dynamics in rad12 mutants of Coprinus cinereus.
Article in Chromosoma, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Sexual spores in mushrooms: bioactive compounds, factors and molecular mechanisms of spore formation.Archives of microbiology · 2025Review
- An MSH4 homolog, stpp1, from Pleurotus pulmonarius is a "silver bullet" for resolving problems caused by spores in cultivated mushrooms.Applied and environmental microbiology · 2013Article
- Global gene expression in Coprinopsis cinerea meiotic mutants reflects checkpoint arrest.G3 (Bethesda, Md.) · 2012Article
- Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus.Chromosoma · 2009Article
- Coprinus cinereus Mer3 is required for synaptonemal complex formation during meiosis.Chromosoma · 2009Article
- Article
- The multiple roles of the Mre11 complex for meiotic recombination.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
- DNA topoisomerase II interacts with Lim15/Dmc1 in meiosis.Nucleic acids research · 2005Article
- Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.Chromosoma · 2004Article
- The Coprinus cinereus adherin Rad9 functions in Mre11-dependent DNA repair, meiotic sister-chromatid cohesion, and meiotic homolog pairing.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Replication-dependent early meiotic requirement for Spo11 and Rad50.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Life history and developmental processes in the basidiomycete Coprinus cinereus.Microbiology and molecular biology reviews : MMBR · 2000Review
- Multiple roles of Spo11 in meiotic chromosome behavior.The EMBO journal · 2000Article
- An mre11 mutant of Coprinus cinereus has defects in meiotic chromosome pairing, condensation and synapsis.Genetics · 2000Article
- The rad9 gene of Coprinus cinereus encodes a proline-rich protein required for meiotic chromosome condensation and synapsis.Genetics · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have characterized the phenotypes of three rad12 mutants of the basidiomycete Coprinus cinereus, which were isolated on the basis of sensitivity to ionizing radiation. Electron microscopic studies of meiotic nuclear spreads showed that all three rad12 mutants are defective in chromosomal synapsis. For rad12-1 and rad12-4, very limited assembly of the synaptonemal complex occurs. The phenotype of rad12-15 is less severe and longer stretches of synapsed chromosomes are formed. However, for all three alleles mutant nuclei arrest in a diffuse state with little synaptonemal complex structure. Observations made of spreads of acridine orange-stained meiotic nuclei correlated with the electron microscopic data. In rad12 strains, chromosomes condense but do not pair, and they later arrest in a decondensed state; very few rad12 cells enter metaphase I. Homozygous dikaryons of rad12 mutants produce fruiting bodies with significantly fewer basidiospores than are found in wild-type dikaryons. The viability of these spores is greatly reduced: all spores produced by rad12-1 and rad12-4 mushrooms fail to germinate, while only 16% of rad12-15 spores are viable. Recombination within the tract of the ribosomal RNA gene repeats was not significantly different in the mutants when compared with a wild-type congenic control. Quantitative measurements of oidial survival indicate that all three rad12 alleles are sensitive to gamma radiation but insensitive to UV radiation relative to wild-type strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.