ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery1995
Mutations and immunohistochemistry of p53 and proliferation markers in astrocytic tumors of childhood.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 17 citations in OpenAlex.
- The predictive capability of immunohistochemistry and DNA sequencing for determiningOncotarget · 2019Article
- Revisiting TP53 Mutations and Immunohistochemistry--A Comparative Study in 157 Diffuse Gliomas.Brain pathology (Zurich, Switzerland) · 2015Article
- Molecular genetic changes in a series of neuroepithelial tumors of childhood.Journal of neuro-oncology · 2002Article
- Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases.The American journal of pathology · 2001Article
- Cerebral metastases as first symptom of cancer: a clinico-pathologic study.Journal of neuro-oncology · 2000Article
- ASTROCYTOMAS AND PROGNOSIS-FROM MORPHOLOGY TO TUMOR BIOLOGY.Medical journal, Armed Forces India · 2000Article
- High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors.Brain pathology (Zurich, Switzerland) · 1999Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Thirty cases of hemispheric astrocytic tumors of childhood, consisting of 11 pilocytic astrocytomas, 2 fibrillary astrocytomas, 9 anaplastic astrocytomas, and 8 glioblastomas, were studied for the presence of p53 mutations and for immunohistochemical demonstrations of p53 and proliferation markers PCNA and Ki-67 MIB-1. The study was performed using polymerase chain reaction (PCR)-assisted single-strand conformation polymorphism analysis of exons 5-8 and direct sequence analysis of PCR products. For immunohistochemistry, DO1 and PAb 1801 were used. No mutation and no positivity for p53 protein were found in pilocytic astrocytomas. Mutations (at codons 144, 202, and 245) were found in 2 out of 8 glioblastomas and in 1 out of 9 anaplastic astrocytomas, whereas positive staining was found in 11 out of 17 malignant gliomas. Cases with mutations showed the highest p53 labeling index and also PCNA and MIB-1 labeling indices. The negative results in pilocytic astrocytomas are in line with the benign course of these tumors, whereas for malignant gliomas no difference seems to exist in comparison with adult cases.
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