ArticleMolecular medicine (Cambridge, Mass.)1995
Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.
Article in Molecular medicine (Cambridge, Mass.), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 99 citations in OpenAlex.
- Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.Cancers · 2026Review
- Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.International journal of molecular sciences · 2022Article
- Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line.Frontiers in immunology · 2022Article
- B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making.Frontiers in oncology · 2020Review
- Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.BMC cancer · 2017Article
- High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis.Blood advances · 2017Article
- Article
- EBV Persistence--Introducing the Virus.Current topics in microbiology and immunology · 2015Review
- Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.PLoS pathogens · 2014Article
- Paediatric orofacial tumours: new oral health concern in paediatric patients.Ghana medical journal · 2014Article
- Targeting pathological B cell receptor signalling in lymphoid malignancies.Nature reviews. Drug discovery · 2013Review
- Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity.Genes and immunity · 2012Article
- Pathogenesis of human B cell lymphomas.Annual review of immunology · 2012Review
- HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma.Immunologic research · 2010Review
- Article
- Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach.Journal of hematopathology · 2008Article
- The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.PLoS biology · 2008Article
- Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires.Biology direct · 2006Article
- Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe developmental stage from which stems the malignant B cell population in Burkitt's lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rear-ranged immunoglobulin (Ig) variable region (V) genes from BL for evidence of somatic mutations, together with a phenotypic characterization. As somatic hypermutation of Ig V region genes occurs in germinal center B cells, somatically mutated Ig genes are found in germinal center B cells and their descendents. MATERIALS AND
methodsRearranged V kappa region genes from 10 kappa-expressing sporadic and endemic BL-derived cell lines (9 IgM and 1 IgG positive) and three kappa-expressing endemic BL biopsy specimens were amplified by polymerase chain reaction and sequenced. In addition, VH region gene sequences from these cell lines were determined.
resultsAll BL cell lines and the three biopsy specimens carried somatically mutated V region genes. The average mutation frequency of rearranged V kappa genes from eight BL cell lines established from sporadic BL was 1.8%. A higher frequency (6%) was found in five endemic cases (three biopsy specimens and two BL cell lines).
conclusionsThe detection of somatic mutations in the rearranged V region genes suggests that both sporadic and endemic BL represent a B-cell malignancy originating from germinal center B cells or their descendants. Interestingly, the mutation frequency detected in sporadic BL is in a range similar to that characteristic for IgM-expressing B cells in the human peripheral blood and for mu chain-expressing germinal center B cells, whereas the mutation frequency found in endemic BL is significantly higher.
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