ReviewJournal of molecular medicine (Berlin, Germany)1995
CD44: physiological expression of distinct isoforms as evidence for organ-specific metastasis formation.
Review in Journal of molecular medicine (Berlin, Germany), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer: Recent Update and Challenges.Pharmaceutics · 2021Review
- Targeting lung cancer stem cells using combination of Tel and Docetaxel liposomes in 3D cultures and tumor xenografts.Toxicology and applied pharmacology · 2020Article
- Mechanistic Insight into Receptor-Mediated Delivery of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantamethamidyl Host:Guest pDNA Nanoparticles to CD44(+) Cells.Molecular pharmaceutics · 2016Article
- CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis.Matrix biology : journal of the International Society for Matrix Biology · 2015Article
- Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype.The Journal of biological chemistry · 2015Article
- Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells.The Journal of biological chemistry · 2015Article
- CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells.Frontiers in immunology · 2015Review
- Polymeric materials for theranostic applications.Pharmaceutical research · 2014Review
- The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression.Glycoconjugate journal · 2007Review
- Induction of anti-tumor immunity by vaccination with dendritic cells pulsed with anti-CD44 IgG opsonized tumor cells.Cancer immunology, immunotherapy : CII · 2006Article
- CD44v6: a target for antibody-based cancer therapy.Cancer immunology, immunotherapy : CII · 2004Review
- The role of alternative splicing of the adhesion molecule, CD44, in lymphoid malignancy.Journal of clinical pathology · 1998Article
- The normal structure and function of CD44 and its role in neoplasia.Molecular pathology : MP · 1998Review
- Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy.The Journal of cell biology · 1998Article
- CD44 in inflammation and metastasis.Glycoconjugate journal · 1997Review
- Serum levels of soluble CD44 variant isoforms are elevated in rheumatoid arthritis.Rheumatology international · 1997Article
- Expression of CD44 splice variants in human skin and epidermal tumours.Virchows Archiv : an international journal of pathology · 1996Article
- Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models.Neoplasia (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous progress has been achieved during recent decades in the therapy of metastasizing malignancies by improving chemotherapeutic strategies and new approaches in radiation therapy. Genetic manipulation of tumor cells and of the tumor fighting immune system is hoped to add significant contributions to curative interventions in disseminated tumors. That we are still far from eradicating death by malignant growth is due ultimately to our limited understanding of the cascade of events resulting in metastasis formation, which until recently was believed to rely on multiple rounds of mutation and selection processes. This implies an individually specific history of each metastatic tumor, which would rule out uniform diagnostic and therapeutic concepts. When it was noted in a rat tumor model that the transfer of cDNA of a single gene, a CD44 variant isoform (CD44v) covering the exons v4-v7, sufficed to initiate metastasis formation of a locally growing tumor, hope was created that a "metastogene" may have been identified. Although the idea of CD44v expression as a unifying concept for tumor progression was not sustained, the discovery of CD44v-initiated metastatic spread allowed a conceptually new hypothesis on tumor progression as a consequence of the reactivation of genetic programs of ontogeny, stem cell differentiation, and/or lymphocyte activation. Since distinct CD44 isoforms play an important role in these processes, unraveling the functions of this family of molecules can indeed provide a cornerstone in the understanding of tumor progression. This article summarizes briefly the present knowledge on known functions of CD44 isoforms with particular focus on parallels between physiological programs and tumor progression.
Indexed as
Identifiers
8528746What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.