ReviewJournal of molecular medicine (Berlin, Germany)1995
Genetic background and environment contribute synergistically to the onset of autoimmune diseases.
Review in Journal of molecular medicine (Berlin, Germany), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of NLRP3 rs35829419 and rs10754558 Polymorphisms With Risks of Autoimmune Diseases: A Systematic Review and Meta-Analysis.Frontiers in genetics · 2021Pooled it
- The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention.Current opinion in immunology · 2023Review
- HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population.BMC dermatology · 2014Article
- Novel avenues of drug discovery and biomarkers for diabetes mellitus.Journal of clinical pharmacology · 2011Review
- Autoimmune joint diseases in Late Medieval skeletal sample from Croatia.Rheumatology international · 2010Article
- Mercury and silver induce B cell activation and anti-nucleolar autoantibody production in outbred mouse stocks: are environmental factors more important than the susceptibility genes in connection with autoimmunity?Clinical and experimental immunology · 2009Article
- Gene-environment interactions in the development of complex disease phenotypes.International journal of environmental research and public health · 2008Article
- Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus.Current neurovascular research · 2007Review
- Mechanistic insights into diabetes mellitus and oxidative stress.Current medicinal chemistry · 2007Review
- In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype.Arthritis research & therapy · 2006Article
- Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice.Clinical and experimental immunology · 2005Article
- Polymorphism in clinical immunology - From HLA typing to immunogenetic profiling.Journal of translational medicine · 2003Article
- Familial autoimmunity and the idiopathic inflammatory myopathies.Current rheumatology reports · 2000Review
- Autoimmunity. Thoughts for the millennium.Clinical reviews in allergy & immunology · 2000Review
- Evidence for the role of environmental agents in the initiation or progression of autoimmune conditions.Environmental health perspectives · 1999Review
- Superantigens in insulin-dependent diabetes mellitus.Springer seminars in immunopathology · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune diseases result from the breakdown of "self" tolerance. Environmental factors appear to be responsible for triggering this errant immune response, directed against self-tissue determinants, only when a susceptible genetic background is present in an individual. Autoimmune diseases, normally characterized by their association with certain HLA alleles, also share other features: the presence of autoantibodies, autoreactive T lymphocytes, and an intermittent clinical course of exacerbations and remissions. In cases of organ-specific diseases, as well as in cases of multi-system autoimmune diseases, viruses are increasingly implicated as such environmental triggers. Current molecular biology techniques have permitted a fine dissection of the genetic background of susceptible individuals and have enabled a more complete characterization of the immunocompetent cells involved in this autoaggression. Molecular approaches will soon allow us to pinpoint the characteristics of the environmental stimuli, so that protective strategies could be formulated to spare susceptible individuals from their ill effects.
Indexed as
Identifiers
8528740What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.