ArticleBritish journal of clinical pharmacology1995
The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler.
Article in British journal of clinical pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inhalation devices.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2005Guideline
- Canadian Asthma Consensus Report, 1999. Canadian Asthma Consensus Group.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1999Guideline
- Usefulness of Nonvalved Spacers for Administration of Inhaled Steroids in Young Children with Recurrent Wheezing and Risk Factors for Asthma.Canadian respiratory journal · 2018Trial
- Randomized trial of spacers in asthma.Indian journal of pediatrics · 2007Trial
- Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge.Archives of disease in childhood · 2001Trial
- Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-salbutamol in children.British journal of clinical pharmacology · 1999Trial
- Lung delivery of non-CFC salbutamol via small volume metal spacer and large volume plastic spacer devices compared with an open vent jet nebulizer.British journal of clinical pharmacology · 1998Trial
- Trial
- Inhaled salbutamol delivery in small children with disposable and reusable spacers: an in vitro study.Archives of disease in childhood · 2025Article
- Spacers and Valved Holding Chambers.Journal of aerosol medicine and pulmonary drug delivery · 2025Review
- The effects of airway disease on the deposition of inhaled drugs.Expert opinion on drug delivery · 2024Review
- Optimal administration of bronchodilators with valved holding chambers in preschool children: a review of literature.European journal of pediatrics · 2021Review
- Spacer devices for inhaled therapy: why use them, and how?ERJ open research · 2018Review
- Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT).NPJ primary care respiratory medicine · 2016Review
- Advances in metered dose inhaler technology: hardware development.AAPS PharmSciTech · 2014Review
- The challenge of delivering therapeutic aerosols to asthma patients.ISRN allergy · 2013Article
- Aerosol therapy for obstructive lung diseases: device selection and practice management issues.Chest · 2011Review
- Use of inhaler devices in pediatric asthma.Paediatric drugs · 2003Review
- A comparative analysis of the particle size output of beclomethasone diproprionate, salmeterol xinafoate and fluticasone propionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer devices.British journal of clinical pharmacology · 1999Article
- Aerosol electrostatics. I: Properties of fine powders before and after aerosolization by dry powder inhalers.Pharmaceutical research · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multistage liquid impinger was used to determine the amount of budesonide available from the Nebuhaler spacer device following alteration of spacer static charge, delay in sampling from the spacer, and multiple actuations of the metered dose inhaler into the spacer prior to sampling. The mean amount of budesonide (s.d.) recovered per 200 micrograms actuation in particles smaller than 5 microns increased from 30.5 micrograms (8.8) to 69.3 micrograms (17.9) with a low static spacer. A 20 s delay between actuation and inhalation reduced the amount recovered to 10.9 micrograms (3.2), but no reduction was seen when using a low static spacer after the same delay. Multiple actuations into the spacer before sampling also reduced the recovery to 24.8 micrograms (3.4) after two actuations, and 13.5 micrograms (7.6) after five actuations. When using a Nebuhaler with budesonide metered dose inhalers, more respirable drug will be obtained if the aerosol is inhaled immediately after actuation, and multiple actuations into the spacer device are avoided. Low static spacers may also improve drug delivery. Attention to the details of spacer use may reduce the incidence of therapeutic failure and the cost of inhaled medications.
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