ArticleArchives of toxicology1995
Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts.
Article in Archives of toxicology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Arsenome, Arsenobolome, and Arsenobiolome.International journal of molecular sciences · 2025Review
- Alternations of Fertility Parameters by Graded Dose of Inorganic Arsenic in Adult Male White Pekin Ducks.Biological trace element research · 2023Article
- Article
- Grapevine trunk diseases of cold-hardy varieties grown in Northern Midwest vineyards coincide with canker fungi and winter injury.PloS one · 2022Article
- The role of autophagy in metal-induced urogenital carcinogenesis.Seminars in cancer biology · 2021Review
- Nanoceria distribution and effects are mouse-strain dependent.Nanotoxicology · 2020Article
- Non-redox cycling mechanisms of oxidative stress induced by PM metals.Free radical biology & medicine · 2020Review
- Article
- Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh.Toxicology and applied pharmacology · 2014Article
- Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2012Article
- Heavy metal poisoning and cardiovascular disease.Journal of toxicology · 2011Article
- Oxidative damage in lymphocytes of copper smelter workers correlated to higher levels of excreted arsenic.Mediators of inflammation · 2010Article
- Inhibition by methylated organo-arsenicals of the respiratory 2-oxo-acid dehydrogenases.Journal of organometallic chemistry · 2009Article
- A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn.Journal of clinical biochemistry and nutrition · 2007Article
- Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.Molecular and cellular biochemistry · 2005Article
- Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.Environmental health perspectives · 2002Article
- Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water.Environmental health perspectives · 2002Article
- Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan.Environmental health perspectives · 2001Article
- Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways.The Biochemical journal · 2001Article
- Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaks in PHA-stimulated and unstimulated human lymphocytes.Environmental health perspectives · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have shown that oxygen radicals can be produced during arsenic metabolism. We report here that in human fibroblasts (HFW cells) sodium arsenite exposure caused increased formation of fluorescent dichlorofluorescein (DCF) by oxidation of the nonfluorescent form. The enhanced DCF fluorescence was inhibited by a radical scavenger, butylated hydroxytoluene. The effects of sodium arsenite treatment on cellular antioxidant activities were then examined. Treatment of HFW cells with sodium arsenite resulted in a significant increase in heme oxygenase activity and ferritin level. Sodium arsenite-enhanced heme oxygenase synthesis was inhibited by co-treatment of cells with the antioxidants sodium azide and dimethyl sulfoxide. Furthermore, sodium arsenite treatment did not apparently affect glucose-6-phosphate dehydrogenase activity, but resulted in significantly increased glutathione levels and superoxide dismutase activity, slightly decreased glutathione peroxidase activity, and significantly decreased catalase activity. Sodium arsenite toxicity was partly reduced by addition of catalase to the culture medium. These results imply that arsenite can enhance oxidative stress in HFW cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.