ArticleActa neuropathologica1995
Role of HIV in the pathogenesis of distal symmetrical peripheral neuropathy.
Article in Acta neuropathologica, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- Pathogenic mechanisms of human immunodeficiency virus (HIV)-associated pain.Molecular psychiatry · 2023Review
- Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.Pharmacological research · 2023Article
- The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa.Frontiers in immunology · 2021Review
- Nitrosative damage during retrovirus infection-induced neuropathic pain.Journal of neuroinflammation · 2018Article
- Gene therapy with HSV encoding p55TNFR gene for HIV neuropathic pain: an evidence-based mini-review.Translational perioperative and pain medicine · 2017Article
- Peripheral neuropathy in primary HIV infection associates with systemic and central nervous system immune activation.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Animal models of HIV peripheral neuropathy.Future virology · 2014Article
- The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain.Current neuropharmacology · 2013Article
- Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons.Experimental neurology · 2008Article
- Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain.Brain : a journal of neurology · 2007Article
- Neuromuscular complications in HIV.Current neurology and neuroscience reports · 2004Review
- Peripheral neuropathies in HIV-infected patients in the era of HAART.Brain pathology (Zurich, Switzerland) · 2003Review
- Autonomic neuropathy in patients with HIV: course, impact of disease stage, and medication.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2000Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the results of a clinical, electrophysiological and pathological study conducted in 18 AIDS patients presenting a distal symmetrical predominantly sensory polyneuropathy (DSPN) characterized by painful dysesthesias as main complaint. Onset of the neuropathy was at CDC (Center for Disease Control) stage II in 2 patients, at CDC stage III in 5 patients and at CDC stage IV in the remainder. Electrophysiological investigation confirmed the presence of an axonal alteration in the sensory nerves, but also revealed motor involvement in all cases. The neuropathological features of sensory nerves were fiber loss and axonal degeneration with macrophagic activation. The expression of monocyte-macrophage markers and of major histocompatibility complex class II antigens appeared up-regulated in endoneurial ramified cells, while expression of CR3, a complement receptor involved in the process of phagocytosis, was down-regulated. In six nerve biopsy samples and in two out of five DSPN dorsal root ganglia we found HIV-related mRNA and protein located in scattered cells of the endoneurium which we presume to be macrophages. These data suggest that: (a) DSPN may occur early in the course of the disease and is not limited to later stages; (b) DSPN is not a ganglionitis but is actually a sensory-motor neuropathy; (c) the virus enters the peripheral nervous system and induces changes in the immunocompetent cell population with activation of macrophages. Storage of the virus inside macrophages may act both as a reservoir for the virus and as a putative cause of nerve damage, probably through release of cytotoxins and/or interaction with trophic factors.
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