ArticleProceedings of the National Academy of Sciences of the United States of America1995
Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus.Frontiers in microbiology · 2021Article
- Female genital tract shedding of HIV-1 is rare in women with suppressed HIV-1 in plasma.AIDS (London, England) · 2020Article
- A recombinant avian leukosis virus subgroup j for directly monitoring viral infection and the selection of neutralizing antibodies.PloS one · 2014Article
- Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE.Retrovirology · 2012Article
- Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- Article
- TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.PLoS pathogens · 2008Article
- Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays.Journal of virology · 2007Article
- Structural and functional analysis of the RNA transport element, a member of an extensive family present in the mouse genome.Journal of virology · 2005Article
- Retroviral mRNA nuclear export elements regulate protein function and virion assembly.The EMBO journal · 2004Article
- Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals: application to HIV-1 INS.Nucleic acids research · 2003Article
- Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway.Journal of virology · 2002Article
- Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.Journal of virology · 2001Article
- Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway.Journal of virology · 2000Article
- Rous sarcoma virus direct repeat cis elements exert effects at several points in the virus life cycle.Journal of virology · 1997Article
- Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.Journal of virology · 1997Article
- Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.Journal of virology · 1997Article
- Avian retroviral RNA element promotes unspliced RNA accumulation in the cytoplasm.Journal of virology · 1996Article
- Gene transfer into mammalian cells by a Rous sarcoma virus-based retroviral vector with the host range of the amphotropic murine leukemia virus.Journal of virology · 1996Article
- Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human immunodeficiency virus type 1-infected cells, the efficient expression of viral proteins from unspliced and singly spliced RNAs is dependent on two factors: the presence in the cell of the viral protein Rev and the presence in the viral RNA of the Rev-responsive element (RRE). We show here that the HIV-1 Rev/RRE system can increase the expression of avian leukosis virus (ALV) structural proteins in mammalian cells (D-17 canine osteosarcoma) and promote the release of mature ALV virions from these cells. In this system, the Rev/RRE interaction appears to facilitate the export of full-length unspliced ALV RNA from the nucleus to the cytoplasm, allowing increased production of the ALV structural proteins. Gag protein is produced in the cytoplasm of the ALV-transfected cells even in the absence of a Rev/RRE interaction. However, a functional Rev/RRE interaction increases the amount of Gag present intracellularly and, more strikingly, results in the release of mature ALV particles into the supernatant. RCAS virus containing an RRE is replication-competent in chicken embryo fibroblasts; however, we have been unable to determine whether the particles produced in D-17 cells are as infectious as the particles produced in chicken embryo fibroblasts.
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