Evidence map›Paper›PMID 8524854›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1995

Human neoplasms elicit multiple specific immune responses in the autologous host.

U Sahin, O Türeci, H Schmitt, B Cochlovius, T Johannes, R Schmits, F Stenner, G Luo, I Schobert, M Pfreundschuh

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01445132 (Adoptive Cell Therapy for B-Cell Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation With Costimulated, Tumor-Derived Lymphocytes), which is not on this map. Cited by 323 papers.

0numbers the graph read from it
0cells of the map it votes in
323citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01445132 phase1completednot on this mapstarted 2007, after this paper: background citation

Adoptive Cell Therapy for B-Cell Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation With Costimulated, Tumor-Derived Lymphocytes

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2007 to 2013Enrolled11ConditionsChronic Lymphocytic LeukemiaArmsAllogeneic Cell Therapy w/ Tumor-derived Lypho
3 · Its place in the literature

Who cites it

323 citing papers in PubMed.

  1. Trial
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  4. Multiplexed Detection of Autoantibodies to Glycopeptides Using Microarray.Methods in molecular biology (Clifton, N.J.) · 2026
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263 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

U SahinMedizinische Klinik und Poliklinik, Innere Medizin I, University of Saarland Medical School, Homburg, Germany.
O Türeci
H Schmitt
B Cochlovius
T Johannes
R Schmits
F Stenner
G Luo
I Schobert
M Pfreundschuh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG antibodies in autologous patient serum lead to the discovery of at least four antigens with a restricted expression pattern in each tumor. Besides antigens known to elicit T-cell responses, such as MAGE-1 and tyrosinase, numerous additional antigens that were overexpressed or specifically expressed in tumors of the same type were identified. Sequence analyses suggest that many of these molecules, besides being the target of a specific immune response, might be of relevance for tumor growth. Antibodies to a given antigen were usually confined to patients with the same tumor type. The unexpected frequency of human tumor antigens, which can be readily defined at the molecular level by the serological analysis of autologous tumor cDNA expression cloning, indicates that human neoplasms elicit multiple specific immune responses in the autologous host and provides diagnostic and therapeutic approaches to human cancer.

Indexed as

Antibodies, NeoplasmAntigens, NeoplasmAstrocytomaBlotting, NorthernBrain NeoplasmsCarcinomaCloning, MolecularDNA, ComplementaryHodgkin DiseaseHumansKidney NeoplasmsMelanomaMolecular Sequence DataNeoplasmsRecombinant ProteinsSequence HomologyAntibodies, NeoplasmAntigens, NeoplasmDNA, ComplementaryRecombinant Proteins

Identifiers

PMID8524854
PMCPMC40492

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.