ArticleProceedings of the National Academy of Sciences of the United States of America1995
Specific activation in jun-transformed avian fibroblasts of a gene (bkj) related to the avian beta-keratin gene family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Folding Keratin Gene Clusters during Skin Regional Specification.Developmental cell · 2020Article
- Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules.Development, growth & differentiation · 2019Article
- Constitutive activation and overexpression of NF-κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis.Oncotarget · 2018Article
- Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles.BMC evolutionary biology · 2014Article
- Genomic organization, transcriptomic analysis, and functional characterization of avian α- and β-keratins in diverse feather forms.Genome biology and evolution · 2014Article
- Genomic organization and molecular phylogenies of the beta (beta) keratin multigene family in the chicken (Gallus gallus) and zebra finch (Taeniopygia guttata): implications for feather evolution.BMC evolutionary biology · 2010Article
- Article
- Genomic organization, annotation, and ligand-receptor inferences of chicken chemokines and chemokine receptor genes based on comparative genomics.BMC genomics · 2005Article
- Article
- v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1.Oncogene · 2003Article
- JAC, a direct target of oncogenic transcription factor Jun, is involved in cell transformation and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Review
- Jun, the oncoprotein.Oncogene · 2001Review
- Expression of a down-regulated target, SSeCKS, reverses v-Jun-induced transformation of 10T1/2 murine fibroblasts.Oncogene · 2001Article
- Identification and characterization of genes upregulated in cells transformed by v-Jun.Oncogene · 2000Article
- Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.The EMBO journal · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed differential gene expression in normal versus jun-transformed avian fibroblasts by using subtracted nucleic acid probes and differential nucleic acid hybridization techniques for the isolation of cDNA clones. One clone corresponded to a gene that was strongly expressed in a previously established quail (Coturnix japonica) embryo fibroblast line (VCD) transformed by a chimeric jun oncogene but whose expression was undetectable in normal quail embryo fibroblasts. Furthermore, the gene was expressed in quail or chicken fibroblast cultures that were freshly transformed by retroviral constructs carrying various viral or cellular jun alleles and in chicken fibroblasts transformed by the avian retrovirus ASV17 carrying the original viral v-jun allele. However, its expression was undetectable in a variety of established avian cell lines or freshly prepared avian fibroblast cultures transformed by other oncogenes or a chemical carcinogen. The nucleotide and deduced amino acid sequences of the cDNA clone were not identical to any sequence entries in the data bases but revealed significant similarities to avian beta-keratin genes; the highest degree of amino acid sequence identity was 63%. The gene, which we termed bkj, may represent a direct or indirect target for jun function.
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