ArticleProceedings of the National Academy of Sciences of the United States of America1995
Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 91 citations in OpenAlex.
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- Cytokine-induced cytokine production by conventional and innate lymphoid cells.Trends in immunology · 2012Review
- Reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types.Frontiers in neural circuits · 2009Article
- A dimer-specific function of the transcription factor NFATp.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells.Blood · 2007Article
- Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells.Immunology · 2006Article
- Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization.The Journal of experimental medicine · 2003Article
- NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.Clinical microbiology reviews · 2002Review
- Characterization of a novel negative regulatory element in the human interleukin 4 promoter.Leukemia · 2000Article
- Review
- Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1.Molecular and cellular biology · 1999Article
- The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway.The EMBO journal · 1998Article
- HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of individual CD4+ T cells results in differential lymphokine expression: interleukin 2 (IL-2) is preferentially produced by T helper type 1 (TH1) cells, which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells, which are essential for humoral immunity. The Ca(2+)-dependent factor NF-ATp plays a key role in the inducible transcription of both these lymphokine genes. However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C-dependent signals, we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells. This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence, an element located 69 bp upstream of the IL4 transcription initiation site. Human IL4 promoter-mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B-activating cytokine tumor necrosis factor alpha and suppressed in RelA-overexpressing cells. In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence, which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA. Thus, competition between two general transcriptional activators, RelA and NF-ATp, mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells.
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