ArticleProceedings of the National Academy of Sciences of the United States of America1995
Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Review
- MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10.Journal of Cancer · 2020Article
- Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major.Frontiers of medicine · 2017Article
- Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells.BMC cancer · 2015Article
- Regulation of breast cancer and bone metastasis by microRNAs.Disease markers · 2013Review
- Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization.The EMBO journal · 2012Article
- MicroRNA: Biogenesis, Function and Role in Cancer.Current genomics · 2010Article
- Circulating microRNAs: novel biomarkers for esophageal cancer.World journal of gastroenterology · 2010Review
- The microRNA network and tumor metastasis.Oncogene · 2010Review
- S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.British journal of cancer · 2009Article
- The dimensions and composition of stereociliary rootlets in mammalian cochlear hair cells: comparison between high- and low-frequency cells and evidence for a connection to the lateral membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?Cancer gene therapy · 2008Review
- Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.Oncogene · 2005Article
- Specific features of neuronal size and shape are regulated by tropomyosin isoforms.Molecular biology of the cell · 2005Article
- Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.The Journal of cell biology · 2004Article
- Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma.Oncogene · 2004Article
- Gamma tropomyosin gene products are required for embryonic development.Molecular and cellular biology · 2004Article
- Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma.British journal of cancer · 2003Article
- Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4.Oncogene · 2003Article
- Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variants of chemically immortalized Syrian hamster embryo cells that had either retained (supB+) or lost (supB-) the ability to suppress tumorigenicity when hybridized with a fibrosarcoma cell line were subcloned. Both supB cell types are nontumorigenic; however, the supB- but not supB+ cells exhibit conditional anchorage-independent growth. Alterations of actin microfilament organization were observed in supB- but not supB+ cells that corresponded to a significant reduction of the actin-binding protein tropomyosin 1 (TM-1) in subB- cells. To examine the possibility of a direct relationship between TM-1 expression and the subB- phenotype, subB+ cells were transfected with an expression vector containing the TM-1 cDNA in an antisense orientation. The antisense-induced reduction of TM-1 levels in supB+ clones caused a microfilament reorganization and conferred anchorage-independent growth potential that were indistinguishable from those characteristic of supB- cells. These data provide direct evidence that TM-1 regulates both microfilament organization and anchorage-independent growth and suggest that microfilament alterations are sufficient for anchorage-independent growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.