ArticleProceedings of the National Academy of Sciences of the United States of America1995
Transport of cytoskeletal elements in the squid giant axon.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Processive flow by biased polymerization mediates the slow axonal transport of actin.The Journal of cell biology · 2019Article
- Enhanced axonal transport: A novel form of "plasticity" after primate and rodent spinal cord injury.Experimental neurology · 2018Article
- The nano-architecture of the axonal cytoskeleton.Nature reviews. Neuroscience · 2017Review
- SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain.Journal of cell science · 2017Article
- Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis.Journal of visualized experiments : JoVE · 2016Article
- Nanoparticles in the brain: a potential therapeutic system targeted to an early defect observed in many neurodegenerative diseases.Pharmaceutical research · 2013Review
- Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.Physical biology · 2012Article
- Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon.Biology open · 2012Article
- Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport.The EMBO journal · 2010Article
- No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome.NeuroImage · 2007Article
- A peptide zipcode sufficient for anterograde transport within amyloid precursor protein.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Quantitative microinjection of oocytes, eggs, and embryos.Methods in cell biology · 2004Review
- Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease.Aging cell · 2003Article
- Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.Molecular biology of the cell · 2001Article
- Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Microtubule transport from the cell body into the axons of growing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to explore how cytoskeletal proteins are moved by axonal transport, we injected fluorescent microtubules and actin filaments as well as exogenous particulates into squid giant axons and observed their movements by confocal microscopy. The squid giant axon is large enough to allow even cytoskeletal assemblies to be injected without damaging the axon or its transport mechanisms. Negatively charged, 10- to 500-nm beads and large dextrans moved down the axon, whereas small (70 kDa) dextrans diffused in all directions and 1000-nm beads did not move. Only particles with negative charge were transported. Microtubules and actin filaments, which have net negative charges, made saltatory movements down the axon, resulting in a net rate approximating that previously shown for slow transport of cytoskeletal elements. The present observations suggest that particle size and charge determine which materials are transported down the axon.
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