ArticleNucleic acids research1995
CCAAT-box binding protein NF-Y (CBF, CP1) recognizes the minor groove and distorts DNA.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- miR169 and PmRGL2 synergistically regulate the NF-Y complex to activate dormancy release in Japanese apricot (Prunus mume Sieb. et Zucc.).Plant molecular biology · 2021Article
- The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation.Frontiers in microbiology · 2019Review
- Deciphering the Molecular Mechanisms Underpinning the Transcriptional Control of Gene Expression by Master Transcriptional Regulators in Arabidopsis Seed.Plant physiology · 2016Article
- Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene.Journal of biosciences · 2015Article
- Article
- AP-1 binding transcriptionally regulates human neutral ceramidase.Archives of biochemistry and biophysics · 2011Article
- Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness.Molecular pharmacology · 2011Article
- Regulation of major histocompatibility complex class II genes.Current opinion in immunology · 2011Review
- Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site.Nucleic acids research · 2009Article
- Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.Plant physiology · 2009Article
- Microarray analysis of the in vivo sequence preferences of a minor groove binding drug.BMC genomics · 2008Article
- DNA compaction by the nuclear factor-Y.Biophysical journal · 2007Article
- The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.Nucleic acids research · 2007Article
- NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner.Gene expression · 2005Article
- Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.The Journal of biological chemistry · 2004Article
- A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone.The Journal of biological chemistry · 2004Article
- Modulation of DNA topoisomerase II alpha promoter activity by members of the Sp (specificity protein) and NF-Y (nuclear factor Y) families of transcription factors.The Biochemical journal · 2003Article
- Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.Immunologic research · 2003Review
- Characterization of the human ephrin-A4 promoter.The Biochemical journal · 2002Article
- Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CCAAT box is one of the most common promoter elements. The evolutionarily conserved heteromeric factor NF-Y binds this sequence with high affinity and specificity. By comparing the methylation interference patterns of different sites, performing electrophoretic mobility shift assays (EMSA) with IC-substituted oligonucleotides and competition experiments with the minor groove binding (MGB) drugs distamicin A, tallimustine and Hoechst 33258 we show that NF-Y makes key minor groove interactions. Circular permutation assays on four CCAAT boxes, MHC Class II Ea, HSP70, epsilon-globin and MSV, indicate that NF-Y is able to distort the double helix by angles of 62-82 degrees, depending on the site used, and suggest that nucleotides flanking the CCAAT pentanucleotide influence the degree of bending.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.