ArticleMolecular and cellular biology1996
Quantitative discrimination of MEF2 sites.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
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- Genome-Wide Analysis Reveals Changes in Polled Yak Long Non-coding RNAs in Skeletal Muscle Development.Frontiers in genetics · 2020Article
- An ATAC-seq atlas of chromatin accessibility in mouse tissues.Scientific data · 2019Article
- 70ProPred: a predictor for discovering sigma70 promoters based on combining multiple features.BMC systems biology · 2018Article
- CAPE increases the expression of SOD3 through epigenetics in human retinal endothelial cells.Journal of clinical biochemistry and nutrition · 2017Article
- Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation.Frontiers in oncology · 2014Review
- Alternative polyadenylation in glioblastoma multiforme and changes in predicted RNA binding protein profiles.Omics : a journal of integrative biology · 2013Article
- Article
- Article
- Position weight matrix, gibbs sampler, and the associated significance tests in motif characterization and prediction.Scientifica · 2012Review
- Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk.Oncogene · 2011Article
- Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer.Skeletal muscle · 2011Article
- Lineage-based primary muscle fiber type diversification independent of MEF2 and NFAT in chick embryos.Journal of muscle research and cell motility · 2011Article
- Discovery of BRM Targeted Therapies: Novel Reactivation of an Anti-cancer Gene.Letters in drug design & discovery · 2011Article
- Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment.Journal of molecular biology · 2010Article
- Identification of two regulatory binding sites which confer myotube specific expression of the mono-ADP-ribosyltransferase ART1 gene.BMC molecular biology · 2008Article
- Low nucleosome occupancy is encoded around functional human transcription factor binding sites.BMC genomics · 2008Article
- In silico detection of sequence variations modifying transcriptional regulation.PLoS computational biology · 2008Article
- Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver--a role for growth hormone in alternative exon usage.BMC molecular biology · 2007Article
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1 author.
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Abstract
Myocyte-specific enhancer factor 2 (MEF2) is a family of closely related transcription factors that play a key role in the differentiation of muscle tissues and are important in the muscle-specific expression of a number of genes. Given the centrality of MEF2 in muscle differentiation, regulatory regions newly determined to be muscle specific are often studied for potential MEF2 binding sites. Possible sites are often located by comparison to a homologous gene or by matching to the consensus MEF2 sequence. Enough data have accumulated that a richer description of the MEF2 binding site, a position weight matrix, can be reliably constructed and its usefulness can be assessed. It was shown that scores from such a matrix approximate MEF2 binding energy and enable recognition of naturally occurring MEF2 sites with high sensitivity and specificity. Regulation of genes via MEF2-like sites is complicated by the fact that a number of transcription factors are involved. Not only is MEF2 itself a family of proteins, but several other, nonhomologous, transcription factors overlap MEF2 in DNA-binding specificity. Thus, more quantitative methods for recognizing potential sites may help with the lengthy process of disentangling the complex regulatory circuits of muscle-specific expression.
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