ArticleMolecular and cellular biology1996
Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 162 citations in OpenAlex.
- Exosomes released by environmental pollutant-stimulated Keratinocytes/PBMCs can trigger psoriatic inflammation in recipient cells via the AhR signaling pathway.Frontiers in molecular biosciences · 2023Article
- Review
- The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model.Chemical research in toxicology · 2020Review
- Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling.The European journal of neuroscience · 2020Article
- NAP Family CG5017 Chaperone Pleiotropically Regulates Human AHR Target Genes Expression inInternational journal of molecular sciences · 2018Article
- Article
- Aryl hydrocarbon receptor-deficient mice are protected from high fat diet-induced changes in metabolic rhythms.Chronobiology international · 2017Article
- Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction.Environmental health insights · 2016Review
- Functional analysis of the dioxin response elements (DREs) of the murine CYP1A1 gene promoter: beyond the core DRE sequence.International journal of molecular sciences · 2014Article
- The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development.PloS one · 2014Article
- HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions.Molecules and cells · 2014Article
- A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes.Molecular & cellular proteomics : MCP · 2010Article
- Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.Toxicology letters · 2010Article
- Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis.The Journal of biological chemistry · 2010Article
- Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).The Journal of biological chemistry · 2009Article
- Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells.The Journal of nutrition · 2009Article
- Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have analyzed the dioxin-inducible transcriptional control mechanism for the mouse CYP1A1 gene in its native chromosomal context. Our genetic and biochemical studies indicate that a C-terminal segment of the aromatic hydrocarbon receptor (AhR) contains latent transactivation capability and communicates the induction signal from enhancer to promoter. Thus, transactivation and enhancer-promoter communication may be congruent functions of AhR. Both functions require heterodimerization between AhR and the AhR nuclear translocator (Arnt). Our findings also indicate that heterodimerization activates AhR's latent transactivation function and silences that of Arnt. Furthermore, removal of Arnt's transactivation domain does not affect dioxin-induced CYP1A1 transcription in vivo. In addition, our studies demonstrate that dioxin-induced changes in chromatin structure occur by different mechanisms at the CYP1A1 enhancer and promoter and that events at an enhancer can be experimentally dissociated from events at the cognate promoter during mechanistic analyses of mammalian transcription in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.