ArticleMolecular and cellular biology1996
SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 113 citations in OpenAlex.
- The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.Nature communications · 2020Article
- Regulatory functions of the Mediator kinases CDK8 and CDK19.Transcription · 2019Review
- Spontaneous mutations inMicrobial cell (Graz, Austria) · 2018Article
- Determinants of selection in yeast evolved by genome shuffling.Biotechnology for biofuels · 2018Article
- Mediator kinase module and human tumorigenesis.Critical reviews in biochemistry and molecular biology · 2015Review
- Mapping small effect mutations in Saccharomyces cerevisiae: impacts of experimental design and mutational properties.G3 (Bethesda, Md.) · 2014Article
- Differential regulation of white-opaque switching by individual subunits of Candida albicans mediator.Eukaryotic cell · 2013Article
- The Mediator complex and transcription elongation.Biochimica et biophysica acta · 2013Review
- The Tlo proteins are stoichiometric components of Candida albicans mediator anchored via the Med3 subunit.Eukaryotic cell · 2012Article
- Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions.PloS one · 2012Article
- Histone modifications influence mediator interactions with chromatin.Nucleic acids research · 2011Article
- Origins and activity of the Mediator complex.Seminars in cell & developmental biology · 2011Review
- Mediator subunits and histone methyltransferase Set2 contribute to Ino2-dependent transcriptional activation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2010Article
- Genome-wide screen of Saccharomyces cerevisiae null allele strains identifies genes involved in selenomethionine resistance.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.Molecular and cellular biology · 2008Article
- Glucose signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.Molecular and cellular biology · 2005Article
- Regulation of transcription by Saccharomyces cerevisiae 14-3-3 proteins.The Biochemical journal · 2004Article
- Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.Molecular biology of the cell · 2004Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
The RNA polymerase II of Saccharomyces cerevisiae exists in holoenzyme forms containing a complex, known as the mediator, associated with the carboxyl-terminal domain. The mediator includes several SRB proteins and is required for transcriptional activation. Previous work showed that a cyclin-dependent kinase-cyclin pair encoded by SSN3 and SSN8, two members of the SSN suppressor family, are identical to two SRB proteins in the mediator. Here we have identified the remaining SSN genes by cloning and genetic analysis. SSN2 and SSN5 are identical to SRB9 and SRB8, respectively, which encode additional components of the mediator. Genetic evidence implicates the SSN genes in transcriptional repression. Thus, these identities provide genetic insight into mediator and carboxyl-terminal domain function, strongly suggesting a role in mediating transcriptional repression as well as activation. We also show that SSN4 and SSN7 are the same as SIN4 and ROX3, respectively, raising the possibility that these genes also encode mediator proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.