ArticleMolecular and cellular biology1995
Regulation of Raf-1-dependent signaling during early Xenopus development.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation.The FEBS journal · 2014Article
- Suppression of chemically induced and spontaneous mouse oocyte activation by AMP-activated protein kinase.Biology of reproduction · 2013Article
- Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.The Journal of biological chemistry · 2012Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Drosophila-raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos.Genetics · 2001Article
- The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation.Molecular and cellular biology · 1999Article
- Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.Oncogene · 1999Article
- Characterization of p96h2bk: immunoreaction with an anti-Erk(extracellular-signal-regulated kinase) peptide antibody and activity in Xenopus oocytes and eggs.The Biochemical journal · 1998Article
- MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.The EMBO journal · 1997Article
- Regulation of embryonic cell division by a Xenopus gastrula-specific protein kinase.The EMBO journal · 1996Article
- PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation.Mechanisms of developmentArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Raf-1 gene product is activated in response to cellular stimulation by a variety of growth factors and hormones. Raf-1 activity has been implicated in both cellular differentiation and proliferation. We have examined the regulation of the Raf-1/MEK/MAP kinase (MAPK) pathway during embryonic development in the frog Xenopus laevis. We report that Raf-1, MEK, and MAPK activities are turned off following fertilization and remain undetectable up until blastula stages (stage 8), some 4 h later. Tight regulation of the Raf-1/MEK/MAPK pathway following fertilization is crucial for embryonic cell cycle progression. Inappropriate reactivation of MAPK activity by microinjection of oncogenic Raf-1 RNA results in metaphase cell cycle arrest and, consequently, embryonic lethality. Our findings demonstrate an absolute requirement, in vivo, for inactivation of the MAPK signaling pathway to allow normal cell cycle progression during the period of synchronous cell divisions which occur following fertilization. Further, we show that cytostatic factor effects are mediated through MEK and MAPK.
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