ArticleMolecular and cellular biology1995
Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway.PLoS genetics · 2014Article
- Article
- Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.Genetics · 2011Review
- Dse1 may control cross talk between the pheromone and filamentation pathways in yeast.Current genetics · 2009Article
- Role of the cell wall integrity and filamentous growth mitogen-activated protein kinase pathways in cell wall remodeling during filamentous growth.Eukaryotic cell · 2009Article
- Article
- CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure.PLoS biology · 2006Article
- Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Current genetics · 2006Article
- Cell wall integrity signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2005Review
- Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.The Journal of biological chemistry · 2001Article
- Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein.Molecular biology of the cell · 2000Article
- Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast.Genetics · 2000Article
- PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.Molecular and cellular biology · 1999Article
- Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3.Molecular and cellular biology · 1999Article
- The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Mitogen-activated protein kinases: specific messages from ubiquitous messengers.Molecular and cellular biology · 1999Review
- Receptor inhibition of pheromone signaling is mediated by the Ste4p Gbeta subunit.Molecular and cellular biology · 1999Article
- MAP kinase pathways in the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.Genes & development · 1998Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Ste7p and Mkk1p are MEK (MAPK/ERK kinase) family members that function in the mating and cell integrity signal transduction pathways in Saccharomyces cerevisiae. We selected STE7 and MKK1 mutations that stimulated their respective pathways in the absence of an inductive signal. Strikingly, serine-to-proline substitutions at analogous positions in Ste7p (position 368) and Mkk1p (position 386) were recovered by independent genetic screens. Such an outcome suggests that this substitution in other MEKs would exhibit similar properties. The Ste7p-P368 variant has higher basal enzymatic activity than Ste7p but still requires induction to reach full activation. The higher activity associated with Ste7p-P368 allows it to compensate for defects in the cell integrity pathway, but it does so only when it is overproduced or when Ste5p is missing. This behavior suggests that Ste5p, which has been proposed to be a tether for the kinases in the mating pathway, contributes to Ste7p specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.