ArticleMolecular and cellular biology1995
DNA rearrangements in Euplotes crassus coincide with discrete periods of DNA replication during the polytene chromosome stage of macronuclear development.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Sequencing of random Euplotes crassus macronuclear genes supports a high frequency of +1 translational frameshifting.Eukaryotic cell · 2005Article
- Identification of a novel "chromosome scaffold" protein that associates with Tec elements undergoing en masse elimination in Euplotes crassus.Molecular biology of the cell · 2003Article
- Origin usage during euplotes ribosomal DNA amplification.Eukaryotic cell · 2003Article
- Tec3, a new developmentally eliminated DNA element in Euplotes crassus.Eukaryotic cell · 2003Article
- De novo telomere addition to spacer sequences prior to their developmental degradation in Euplotes crassus.Nucleic acids research · 2002Article
- A family of developmentally excised DNA elements in Tetrahymena is under selective pressure to maintain an open reading frame encoding an integrase-like protein.Nucleic acids research · 2000Article
- Timing of developmentally programmed excision and circularization of Paramecium internal eliminated sequences.Molecular and cellular biology · 2000Article
- Differentiation of chromatin during DNA elimination in Euplotes crassus.Molecular biology of the cell · 1999Article
- Conserved DNA sequences adjacent to chromosome fragmentation and telomere addition sites in Euplotes crassus.Nucleic acids research · 1998Article
- Coordinate regulation of G- and C strand length during new telomere synthesis.Molecular biology of the cell · 1997Article
- An unusual histone H3 specific for early macronuclear development in Euplotes crassus.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Timing of differential amplification of macronucleus-destined sequences during macronuclear development in the hypotrichous ciliate Euplotes crassus.Chromosoma · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macronuclear development in Euplotes crassus begins with polytenization of micronuclear chromosomes and is accompanied by highly precise excision of DNA sequences known as internal eliminated sequences and transposon-like elements (Tecs). Quantitation of radiolabeled-precursor incorporation into DNA indicates that DNA synthesis during formation of polytene chromosomes is not continuous and occurs during two distinct periods. We demonstrate that the timing of Tec excision coincides with these replication periods and that excision can occur during both periods even at a single locus. We also show that Tec and internal eliminated sequence excisions are coincident in the second replication period, thus providing further evidence for similarity in their excision mechanism. Inhibition of DNA synthesis with hydroxyurea diminishes Tec element excision, indicating that replication is an important aspect of the excision process.
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