ArticleJournal of neuro-oncology1995
Growth inhibition of human glioma cells modulated by retrovirus gene transfection with antisense IL-8.
Article in Journal of neuro-oncology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- Anti-angiogenic gene therapy in the treatment of malignant gliomas.Neuroscience letters · 2012Review
- IL-8 is a mediator of NF-κB induced invasion by gliomas.Journal of neuro-oncology · 2011Article
- Induced interleukin-8 expression in gliomas by tumor-associated macrophages.Journal of neuro-oncology · 2009Article
- The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.Neuro-oncology · 2005Review
- Article
- Chemokines and glial cells: a complex network in the central nervous system.Neurochemical research · 2004Review
- Transfection of colorectal cancer cells with chemokine MCP-3 (monocyte chemotactic protein-3) gene retards tumor growth and inhibits tumor metastasis.World journal of gastroenterology · 2002Article
- Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of experimental intracranial human malignant glioma.Journal of neuro-oncology · 1999Article
- Suppression of TGF-beta1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells.Journal of neuro-oncology · 1999Article
- Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.Oncogene · 1999Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human glioma cell line, NP-1, expresses IL-8 mRNA and constitutively secretes IL-8 protein. Administration of recombinant IL-8 increased the proliferation of NP-1 cells in a dose-dependent manner. In the presence of anti-IL-8 antiserum, the IL-8 mediated proliferation of NP-1 cell growth was inhibited. Further, NP-1 cell growth was inhibited by transfection of retroviral constructs encoding antisense IL-8 both in vitro and in vivo models. These results suggest that antisense IL-8 gene therapy could be beneficial in gliomas where autocrine stimulation by IL-8 is implicated.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.