ReviewJournal of neuro-oncology1995
Primary central nervous system lymphomas--new pathological developments.
Review in Journal of neuro-oncology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Primary peripheral T-cell central nervous system lymphoma.Surgical neurology international · 2021Article
- High-dose Methotrexate plus temozolomide with or without rituximab in patients with untreated primary central nervous system lymphoma: A retrospective study from China.Cancer medicine · 2019Article
- Mouse models of primary central nervous system lymphomas: tools for basing funding and therapeutic strategies.Journal of neuro-oncology · 2015Review
- Article
- [Primary cerebellar T-cell lymphoma].Der Pathologe · 2008Article
- Article
- Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type.Brain pathology (Zurich, Switzerland) · 2000Article
- Glucocorticoid treatment of primary CNS lymphoma.Journal of neuro-oncology · 1999Review
- Epidemiology of primary CNS lymphoma.Journal of neuro-oncology · 1999Article
- HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma.Brain pathology (Zurich, Switzerland) · 1999Article
- Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.Brain pathology (Zurich, Switzerland) · 1998Article
- Primary cerebral non-Hodgkin's lymphoma (PCNSL): a review of new trends in management.Italian journal of neurological sciences · 1997Review
- Intracerebral Human Lymphoma - An Experimental Model.Pathology oncology research : POR · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary central nervous system lymphomas (PCNSL) show increased incidence both in immunocompromised high-risk groups and in the general population. They are extranodal diffuse non-Hodgkin's lymphomas with a morphology similar to systemic lymphomas, but differ in their biological and molecular behaviour. The majority are large B-cell variants of high-grade malignancy; low-grade subtypes and T-cell lymphomas are rare; up to 50% remain unclassified according to the New Working Formulation and updated Kiel classification. Monoclonality of immunoglobulin receptor gene rearrangement can be diagnostically useful. The pathogenesis of PCNSL is obscure. Epstein-Barr virus (EBV) genome/proteins expression in two-thirds of HIV-related PCNSL but only in 15% of those in immunocompetent patients suggest different EBV latency stages in both types; human herpesvirus type 6 does not appear to play a pathogenic role. Comparison of expression patterns of integrin chains and adhesion molecules are very similar for PCNSL and nodal lymphomas suggesting that they are not selective mediators of lymphoma cell homing to the brain. In HIV-negative PCNSL they appear not to be influenced by EBV. Studies of protooncogenes (bcl-1 and bcl-2 genes) revealed no rearrangement in PCNSL, suggesting that they are not involved in the pathogenesis of PCNSL that probably do not differ cytogenetically from nodal B-cell lymphomas. Since most of the currently known molecular parameters are probably not the primary pathogenic events, the molecular genetics and pathogenesis of PCNSL are still to be elucidated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.