ArticleThe Journal of cell biology1995
Adequate connexin-mediated coupling is required for proper insulin production.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 118 citations in OpenAlex.
- A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice.iScience · 2024Article
- Extracellular electrophysiology on clonal human β-cell spheroids.Frontiers in endocrinology · 2024Article
- Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress.Molecular and cellular endocrinology · 2022Article
- The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets.International journal of molecular sciences · 2020Article
- Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus.Biophysical journal · 2016Article
- Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.The Journal of biological chemistry · 2015Article
- Cardiac to cancer: connecting connexins to clinical opportunity.FEBS letters · 2014Review
- Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets.Diabetologia · 2010Article
- Pancreatic islet cells: a model for calcium-dependent peptide release.HFSP journal · 2010Article
- Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.Human molecular genetics · 2010Article
- Regulation of gap junctional charge selectivity in cells coexpressing connexin 40 and connexin 43.American journal of physiology. Heart and circulatory physiology · 2009Article
- Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.Human molecular genetics · 2009Article
- The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation.Theoretical biology & medical modelling · 2008Article
- Hindered diffusion through an aqueous pore describes invariant dye selectivity of Cx43 junctions.Biophysical journal · 2008Article
- Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation.Circulation research · 2006Article
- Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.Pflugers Archiv : European journal of physiology · 2005Article
- Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription.Molecular biology of the cell · 2005Article
- Excitation wave propagation as a possible mechanism for signal transmission in pancreatic islets of Langerhans.Biophysical journal · 2001Article
- Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.The Journal of clinical investigation · 2000Article
- Gap junctional communication modulates gene expression in osteoblastic cells.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess whether connexin (Cx) expression contributes to insulin secretion, we have investigated normal and tumoral insulin-producing cells for connexins, gap junctions, and coupling. We have found that the glucose-sensitive cells of pancreatic islets and of a rat insulinoma are functionally coupled by gap junctions made of Cx43. In contrast, cells of several lines secreting insulin abnormally do not express Cx43, gap junctions, and coupling. After correction of these defects by stable transfection of Cx43 cDNA, cells expressing modest levels of Cx43 and coupling, as observed in native beta-cells, showed an expression of the insulin gene and an insulin content that were markedly elevated, compared with those observed in both wild-type (uncoupled) cells and in transfected cells overexpressing Cx43. These findings indicate that adequate levels of Cx-mediated coupling are required for proper insulin production and storage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.