ArticleThe Journal of cell biology1995
A localized elevation of cytosolic free calcium is associated with cytokinesis in the zebrafish embryo.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 125 citations in OpenAlex.
- Calcium waves and nuclear tension changes coordinate mechanical stress dissipation in locally folded epithelia.iScience · 2026Article
- Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025Review
- Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis.Molecular biology of the cell · 2022Article
- The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission.Science advances · 2021Article
- Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis.Molecular biology of the cell · 2021Article
- Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo.Development (Cambridge, England) · 2018Article
- Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish.Developmental biology · 2017Article
- [Excessive fluoride inducing calcium overload and apoptosis of ameloblasts].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2014Article
- Effects of soybean agglutinin on mechanical barrier function and tight junction protein expression in intestinal epithelial cells from piglets.International journal of molecular sciences · 2013Article
- Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation.PLoS biology · 2012Article
- Calcium-release channels in paramecium. Genomic expansion, differential positioning and partial transcriptional elimination.PloS one · 2011Article
- Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning.PLoS genetics · 2010Article
- Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish.Molecular reproduction and development · 2010Review
- Cancer as a metabolic disease.Nutrition & metabolism · 2010Article
- Analysis of signaling pathways in zebrafish development by microinjection.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Cell Cycle-Dependent Localization of Voltage-Dependent Calcium Channels and the Mitotic Apparatus in a Neuroendocrine Cell Line(AtT-20).International journal of cell biology · 2009Article
- Calcium signalling in early embryos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Calcium signalling during the cleavage period of zebrafish development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs.Molecular biology of the cell · 2006Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis, a key step in cell division, is known to be precisely regulated both in its timing and location. At present, the regulatory mechanism of cytokinesis is not well understood, although it has been suggested that calcium signaling may play an important role in this process. To test this notion, we introduced a sensitive fluorescent Ca2+ indicator into the zebrafish embryo and used confocal microscopy to measure the spatiotemporal variation of intracellular free Ca2+ concentration ([Ca2+]i) during cell cleavage. It was evident that a localized elevation of [Ca2+]i is closely associated with cytokinesis. First, we found that during cytokinesis, the level of free Ca2+ was elevated locally precisely at the cleavage site. Second, the rise of free Ca2+ was very rapid and occurred just preceding the initiation of furrow contraction. These observations strongly suggest that cytokinesis may be triggered by a calcium signal. In addition, we found that this cytokinesis-associated calcium signal arose mainly from internal stores of Ca2+ rather than from external free Ca2+; it could be blocked by the antagonist of inositol trisphosphate (InsP3) receptors. These findings suggest that the localized elevation of [Ca2+]i is caused by the release of free Ca2+ from the endoplasmic reticulum through the InsP3-regulated calcium channels.
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