ArticleThe EMBO journal1995
Novel location and function of a thyroid hormone response element.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Identification of thyroid hormone response elements in vivo using mice expressing a tagged thyroid hormone receptor α1.Bioscience reports · 2013Article
- The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements.Nucleic acids research · 2005Article
- ChIP Display: novel method for identification of genomic targets of transcription factors.Nucleic acids research · 2004Article
- Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys.Histochemistry and cell biology · 2004Article
- Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor.The EMBO journal · 2003Article
- Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene.Nucleic acids research · 2000Article
- Transcriptional repression by the insulator protein CTCF involves histone deacetylases.Nucleic acids research · 2000Article
- Chromatin immunoselection defines a TAL-1 target gene.The EMBO journal · 1998Article
- Sequence determinants of DNA binding by the hematopoietic helix-loop-helix transcription factor TAL1: importance of sequences flanking the E-box core.Gene expression · 1998Article
- Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.The EMBO journal · 1996Article
- Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation.The EMBO journal · 1996Article
- Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA.Molecular and cellular biology · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We describe a novel thyroid hormone response element (TRE)-containing sequence, clone 144, isolated by immunoprecipitation of nuclear thyroid hormone receptor (TR)-DNA complexes from the rat pituitary tumor cell line GH4. These cells express several mRNAs of approximately 10 kb that hybridize to the TRE-containing genomic clone 144. These mRNAs are up-regulated at the transcriptional level in the absence of thyroid hormone (T3) and repressed in its presence. The sequence protected from DNase I digestion by TR in clone 144 contains two consensus TRE half-sites arranged as inverted palindromes. The clone 144 TRE is located in the 3' untranslated region (UTR) of several related mRNAs. A reporter construct transfected into 293 cells was responsive to TR regulation when the clone 144 TRE was inserted in the 3' UTR but not when inserted upstream of the promoter. As found for the endogenous 144 mRNAs, the 144 TRE reporter construct is activated by TR in the absence of T3, but not in its presence. Deletion analysis showed that clone 144 sequences flanking the TRE were necessary for TR-mediated regulation, suggesting that the mechanism by which TR regulates transcription through a TRE in the 3' UTR is different from that through the TREs located in the promoter region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.