ArticleThe EMBO journal1995
Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 188 citations in OpenAlex.
- Polycomb-mediated transgenerational epigenetic inheritance ofOpen biology · 2025Article
- Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila.Molecular cell · 2025Article
- Differences in temperature-sensitive expression of PcG-regulated genes among natural populations of Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.PLoS genetics · 2020Article
- Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.Annual review of biochemistry · 2020Review
- Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling.Genes & development · 2019Article
- Decreased Temperature Sensitivity ofGenes · 2019Article
- Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4.Developmental cell · 2019Article
- Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.Genome research · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Single vector non-leaky gene expression system for Drosophila melanogaster.Scientific reports · 2017Article
- The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation.Molecular and cellular biology · 2017Article
- Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila.Nature genetics · 2017Article
- Review
- Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.Nature structural & molecular biology · 2016Article
- Article
- RNAi screen in Drosophila larvae identifies histone deacetylase 3 as a positive regulator of the hsp70 heat shock gene expression during heat shock.Biochimica et biophysica acta · 2014Article
- Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW.Genes & development · 2013Article
- Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes of the Polycomb-group (Pc-G) are responsible for maintaining the inactive expression state of homeotic genes. They act through specific cis-regulatory DNA elements termed PREs (Pc-G Response Elements). Multimeric complexes containing the Pc-G proteins are thought to induce heterochromatin-like structures, which stably and heritably inactivate transcription. We have tested the functional role of the FAB fragment, a PRE of the bithorax complex. We find that this element behaves as an orientation dependent silencer, capable of inducing mosaic gene expression on neighboring genes. Transgenic fly lines were constructed containing a PRE adjacent to a reporter gene inducible by the yeast GAL4 trans-activator. The competition between the activator and Pc-G-containing chromatin was visualized on polytene chromosomes using immunocytochemistry. The Pc-G protein Polycomb and GAL4 have mutually exclusive binding patterns, supporting the notion that Pc-G-induced chromatin structures can prevent activators from binding to their target sequences. However, this antagonistic function can be overcome by high doses of GAL4, even in the absence of DNA replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.