ArticleThe EMBO journal1995
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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Who cites it
69 citing papers in PubMed, 287 citations in OpenAlex.
- JAK/STAT: Why choose a classical or an alternative pathway when you can have both?Journal of cellular and molecular medicine · 2022Review
- SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression.Cell death discovery · 2021Article
- AcuteFrontiers in microbiology · 2020Article
- Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.Development (Cambridge, England) · 2018Review
- Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E.Oncotarget · 2017Article
- Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults.Frontiers in physiology · 2016Article
- Article
- The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?Frontiers in physiology · 2013Article
- The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.The Journal of biological chemistry · 2012Article
- The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy.Endocrine · 2012Review
- Biology and significance of the JAK/STAT signalling pathways.Growth factors (Chur, Switzerland) · 2012Review
- Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway.Translational neurodegeneration · 2012Article
- The erythropoietin receptor: molecular structure and hematopoietic signaling pathways.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2011Review
- Alternative activation of macrophages by IL-4 requires SHIP degradation.European journal of immunology · 2011Article
- An extra high dose of erythropoietin fails to support the proliferation of erythropoietin dependent cell lines.Cytotechnology · 2011Article
- STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.The Journal of biological chemistry · 2010Article
- ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling.Blood · 2009Article
- Article
- Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex.Molecular cell · 2009Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While previous studies with truncated erythropoietin receptors (EpRs) have suggested that the tyrosine phosphorylation of the EpR does not play a role in Ep-induced proliferation, we have found, using a more subtle, full length EpR mutant, designated Null, in which all eight of the intracellular tyrosines have been substituted with phenylalanine residues, that Null cells require substantially more Ep than wild-type cells in order to proliferate as efficiently. A comparison of Ep-induced proliferation with Ep-induced tyrosine phosphorylation patterns, using wild-type and Null EpR-expressing cells, revealed that Stat5 tyrosine phosphorylation and activation correlated directly with proliferation. Moreover, studies with a Y343F EpR point mutant and various EpR deletion mutants revealed that both Ep-induced proliferation and Stat5 activation were mediated primarily through Y343, but that other tyrosines within the EpR could activate Stat5 in its absence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.